Evidence map›Paper›PMID 34078750›Full record

ArticleAging2021

GRSF1 deficiency in skeletal muscle reduces endurance in aged mice.

Riley K Driscoll, Linda K Krasniewski, Samuel G Cockey, Jen-Hao Yang, Yulan Piao, Elin Lehrmann, Yongqing Zhang, Marc Michel, Ji Heon Noh, Chang-Yi Cui and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. The HNRNPF/H RNA binding proteins and disease.Wiley interdisciplinary reviews. RNA
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Riley K DriscollLaboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Linda K KrasniewskiLaboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Samuel G CockeyLaboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Jen-Hao YangLaboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Yulan PiaoLaboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Elin LehrmannLaboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Yongqing ZhangLaboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Marc MichelLaboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Ji Heon NohLaboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Chang-Yi CuiLaboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Myriam GorospeLaboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
National Institute on Aging · USNational Institutes of Health · US

Funding

Post-transcriptional regulation of energy usage: glucose and lipid metabolismZIAAG000394 · NIA · NATIONAL INSTITUTE ON AGING · PI GOROSPE, MYRIAM · 2009 to 2025
$18.7M
6 · The paper itself

Abstract

GRSF1 is a mitochondrial RNA-binding protein important for maintaining mitochondrial function. We found that GRSF1 is highly expressed in cultured skeletal myoblasts differentiating into myotubes. To understand the physiological function of GRSF1

Indexed as

Physical EnduranceAgingAnimalsCell DifferentiationGene Expression ProfilingGene Expression RegulationMiceMice, Inbred C57BLMice, KnockoutMuscle CellsMuscle DevelopmentMuscle, SkeletalPoly(A)-Binding ProteinsReactive Oxygen SpeciesRNA, MessengerGrsf1 protein, mousePoly(A)-Binding ProteinsReactive Oxygen SpeciesRNA, MessengerGRSF1mouse agingRNA-binding proteinskeletal muscle aging

Identifiers

PMID34078750
PMCPMC8221292
OpenAlexW3164613509

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.