Evidence map›Paper›PMID 34078641›Full record

ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2021

Function-related Indicators and Outcomes of Screening Mammography in Older Women: Evidence from the Breast Cancer Surveillance Consortium Cohort.

Dongyu Zhang, Linn Abraham, Joshua Demb, Diana L Miglioretti, Shailesh Advani, Brian L Sprague, Louise M Henderson, Tracy Onega, Karen J Wernli, Louise C Walter and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 1 country.

Dongyu ZhangDepartment of Epidemiology, University of Florida College of Public Health and Health Professions, Gainesville, Florida.
Linn AbrahamKaiser Permanente Washington Health Research Institute, Seattle, Washington.ORCID 0000-0002-0840-1947
Joshua DembDivision of Gastroenterology, Department of Internal Medicine, University of California, San Diego, La Jolla, California.
Diana L MigliorettiKaiser Permanente Washington Health Research Institute, Seattle, Washington.ORCID 0000-0002-5547-1833
Shailesh AdvaniTransplant Education Research Center, Terasaki Institute of Biomedical Innovation, Los Angeles, California.
Brian L SpragueDepartment of Surgery, University of Vermont College of Medicine, Burlington, Vermont.
Louise M HendersonDepartment of Radiology, University of North Carolina at Chapel Hill, North Carolina.
Tracy OnegaDepartment of Population Health Sciences, University of Utah, and Huntsman Cancer Institute, Salt Lake City, Utah.
Karen J WernliKaiser Permanente Washington Health Research Institute, Seattle, Washington.
Louise C WalterDepartment of Medicine, University of California, San Francisco, San Francisco, California.
Karla KerlikowskeDepartment of Medicine, University of California, San Francisco, San Francisco, California.
John T SchousboePark Nicollet Clinic and HealthPartners Institute, HealthPartners Inc, Bloomington, Minnesota.
Ellen S O'MearaKaiser Permanente Washington Health Research Institute, Seattle, Washington.ORCID 0000-0002-2997-295X
Dejana Braithwaite
Breast Cancer Surveillance Consortium
Kaiser Permanente Washington Health Research Institute · USUniversity of California, San Francisco · USUniversity of Florida Health · USHuntsman Cancer Institute · USTerasaki Foundation · USUniversity of California San Diego · USUniversity of Minnesota · USUniversity of North Carolina at Chapel Hill · USUniversity of Vermont · US

Funding

Risk-based Imaging Strategies to Improve Breast Cancer Surveillance OutcomesP01CA154292 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KARLA M KERLIKOWSKE · 2011 to 2026
$52.9M
Vermont Screening Process Documentation UnitU54CA163303 · NCI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI SPRAGUE, BRIAN L · 2011 to 2017
$6.4M
Effectiveness of Pre-Operative MRI in Breast Cancer Surgery and OutcomesR01CA149365 · NCI · DARTMOUTH COLLEGE · PI ONEGA, TRACY · 2011 to 2015
$2.8M
COMORBIDITY AND SCREENING OUTCOMES AMONG OLDER WOMEN UNDERGOING MAMMOGRAPHYR01CA207361 · NCI · UNIVERSITY OF FLORIDA · PI BRAITHWAITE, DEJANA K · 2017 to 2020
$2.3M
NCI NIH HHS P01 CA154292NCI NIH HHS R01 CA149365NCI NIH HHS R01 CA207361NCI NIH HHS U54 CA163303
6 · The paper itself

Abstract

backgroundPrevious reports suggested risk of death and breast cancer varied by comorbidity and age in older women undergoing mammography. However, impacts of functional limitations remain unclear.

methodsWe used data from 238,849 women in the Breast Cancer Surveillance Consortium-Medicare linked database (1999-2015) who had screening mammogram at ages 66-94 years. We estimated risk of breast cancer, breast cancer death, and non-breast cancer death by function-related indicator (FRI) which incorporated 16 claims-based items and was categorized as an ordinal variable (0, 1, and 2+). Fine and Gray proportional sub-distribution hazards models were applied with breast cancer and death treated as competing events. Risk estimates by FRI scores were adjusted by age and NCI comorbidity index separately and stratified by these factors.

resultsOverall, 9,252 women were diagnosed with breast cancer, 406 died of breast cancer, and 41,640 died from non-breast cancer causes. The 10-year age-adjusted invasive breast cancer risk slightly decreased with FRI score [FRI = 0: 4.0%, 95% confidence interval (CI) = 3.8-4.1; FRI = 1: 3.9%, 95% CI = 3.7-4.2; FRI ≥ 2: 3.5%, 95% CI = 3.1-3.9). Risk of non-breast cancer death increased with FRI score (FRI = 0: 18.8%, 95% CI = 18.5-19.1; FRI = 1: 24.4%, 95% CI = 23.9-25.0; FRI ≥ 2: 39.8%, 95% CI = 38.8-40.9]. Risk of breast cancer death was low with minimal differences across FRI scores. NCI comorbidity index-adjusted models and stratified analyses yielded similar patterns.

conclusionsRisk of non-breast cancer death substantially increases with FRI score, whereas risk of breast cancer death is low regardless of functional status. IMPACT: Older women with functional limitations should be informed that they may not benefit from screening mammography.

Indexed as

MammographyAgedAged, 80 and overBreast NeoplasmsEarly Detection of CancerFemaleHumansRiskUnited States

Identifiers

PMID34078641
PMCPMC8563300
OpenAlexW3165150102

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.