Evidence map›Paper›PMID 34078530›Full record

ArticleBMB reports2021

Arginase inhibition by rhaponticin increases L-arginine concentration that contributes to Ca

Bon-Hyeock Koo, Jonghoon Lee, Younghyun Jin, Hyun Kyo Lim, Sungwoo Ryoo

Open access · goldAbstract read
In one paragraph

Article in BMB reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Subcellular Localization Guides eNOS Function.International journal of molecular sciences · 2024
    Review
  4. Exercise-Induced Shear Stress Drives mRNA Translation In Vitro.Current issues in molecular biology · 2024
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Bon-Hyeock KooDepartment of Biological Sciences, Kangwon National University, Chuncheon 24341, Korea.
Jonghoon LeeDepartment of Anesthesiology and Pain Medicine, Yonsei University Wonju College of Medicine, Wonju 26426, Korea.
Younghyun JinDepartment of Anesthesiology and Pain Medicine, Yonsei University Wonju College of Medicine, Wonju 26426, Korea.
Hyun Kyo LimDepartment of Anesthesiology and Pain Medicine, Yonsei University Wonju College of Medicine, Wonju 26426, Korea.
Sungwoo RyooDepartment of Biological Sciences, Kangwon National University, Chuncheon 24341, Korea.
Yonsei University · KRKangwon National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although arginase primarily participates in the last reaction of the urea cycle, we have previously demonstrated that arginase II is an important cytosolic calcium regulator through spermine production in a p32-dependent manner. Here, we demonstrated that rhaponticin (RPT) is a novel medicinal-plant arginase inhibitor and investigated its mechanism of action on Ca

Indexed as

AnimalsArginaseArginineCalciumCytosolEndothelial CellsHumansHuman Umbilical Vein Endothelial CellsInositol 1,4,5-Trisphosphate ReceptorsMiceMice, Inbred C57BLMice, KnockoutMitochondrial ProteinsNitric OxideNitric Oxide Synthase Type IIIReactive Oxygen SpeciesArginaseArginineCalciumInositol 1,4,5-Trisphosphate ReceptorsItpr1 protein, mouseMitochondrial ProteinsNitric OxideNitric Oxide Synthase Type IIINos3 protein, mouseReactive Oxygen SpeciesrhapontinStilbenes

Identifiers

PMID34078530
PMCPMC8560459
OpenAlexW3165576074

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.