Evidence map›Paper›PMID 34078506›Full record

ArticleJournal of the International Neuropsychological Society : JINS2022

Impaired Behavioral Pattern Separation in Refractory Temporal Lobe Epilepsy and Mild Cognitive Impairment.

Sanam J Lalani, Anny Reyes, Erik Kaestner, Shauna M Stark, Craig E L Stark, David Lee, Leena Kansal, Jerry J Shih, Christine N Smith, Brianna M Paul and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the International Neuropsychological Society : JINS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Deficits in Behavioral and Neuronal Pattern Separation in Temporal Lobe Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  8. Patterns of Pathology.Epilepsy currents
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Sanam J LalaniDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-7429-2892
Anny ReyesSan Diego State University, University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
Erik KaestnerCenter for Multimodal Imaging and Genetics, University of California, San Diego, CA, USA.
Shauna M StarkDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA, USA.
Craig E L StarkDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, CA, USA.
David LeeDepartment of Neurosciences, University of California San Diego, San Diego, CA, USA.
Leena KansalDepartment of Neurosciences, University of California San Diego, San Diego, CA, USA.
Jerry J ShihDepartment of Neurosciences, University of California San Diego, San Diego, CA, USA.
Christine N SmithDepartment of Psychiatry, University of California, San Diego, CA, USA.
Brianna M PaulDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Carrie R McDonaldSan Diego State University, University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
University of California San Diego · USUniversity of California, Irvine · USSan Diego State University · USUniversity of California, San Francisco · US

Funding

The Alzheimer's Disease Research Center at the University of California, IrvineP30AG066519 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Craig E Stark · 2020 to 2026
$27.9M
Fellowship on Biological Psychiatry and NeuroscienceT32MH018399 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Pei-an (Betty) Shih · 1986 to 2026
$7.3M
Multimodal Imaging of Language in the Preoperative Evaluation of EpilepsyR01NS065838 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCDONALD, CARRIE R · 2010 to 2018
$4.4M
Multimodal imaging of memory in epilepsy from whole brain networks to local neuronal responses: Implications for surgical decision-makingR01NS124585 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCDONALD, CARRIE R · 2022 to 2025
$3.3M
Development of the mnemonic similarity task as a tool to address age and dementia-related memory declineR01AG066683 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI STARK, CRAIG E · 2020 to 2024
$1.9M
Multimodal imaging of memory reorganization in epilepsy from whole brain networks to local neuronal responses: Implications for surgical-decision-makingR56NS065838 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCDONALD, CARRIE R · 2020 to 2020
$467k
Development of a personalized neurostimulation protocol for memory mapping in epilepsyK01NS124831 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KAESTNER, ERIK JORDAN · 2022 to 2024
$339k
Explaining cognitive heterogeneity in temporal lobe epilepsy (TLE): Identifying unique imaging features, health-related risk factors and protective factors in TLE subtypesF31NS111883 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI REYES, ANNY · 2019 to 2021
$89k
NIA NIH HHS P30 AG066519NIA NIH HHS R01 AG066683NIMH NIH HHS T32 MH018399NINDS NIH HHS F31 NS111883NINDS NIH HHS K01 NS124831NINDS NIH HHS R01 NS065838NINDS NIH HHS R01 NS124585NINDS NIH HHS R56 NS065838
6 · The paper itself

Abstract

objectiveEpisodic memory impairment and hippocampal pathology are hallmark features of both temporal lobe epilepsy (TLE) and amnestic mild cognitive impairment (aMCI). Pattern separation (PS), which enables the distinction between similar but unique experiences, is thought to contribute to successful encoding and retrieval of episodic memories. Impaired PS has been proposed as a potential mechanism underling episodic memory impairment in aMCI, but this association is less established in TLE. In this study, we examined behavioral PS in patients with TLE and explored whether profiles of performance in TLE are similar to aMCI.

methodPatients with TLE, aMCI, and age-matched, healthy controls (HCs) completed a modified recognition task that relies on PS for the discrimination of highly similar lure items, the

resultsPatients with TLE and aMCI demonstrated poorer PS performance relative to the HCs, but performance did not differ between the two patient groups. Neither the side of seizure focus nor having hippocampal sclerosis affected performance in TLE. However, TLE patients with clinically defined memory impairment showed the poorest performance.

conclusionMemory performance on a task that relies on PS was disrupted to a similar extent in TLE and aMCI. The MST could provide a clinically useful tool for measuring hippocampus-dependent memory impairments in TLE and other neurological disorders associated with hippocampal damage.

Indexed as

Cognitive DysfunctionEpilepsy, Temporal LobeMemory, EpisodicHippocampusHumansMagnetic Resonance ImagingMemory DisordersNeuropsychological TestsAgingCognitionEpisodic memoryHippocampusMemory impairmentSeizure disorder

Identifiers

PMID34078506
PMCPMC8965747
OpenAlexW3164430843

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.