Evidence map›Paper›PMID 34078406›Full record

ArticleJournal of translational medicine2021

Perspectives in immunotherapy: meeting report from the immunotherapy bridge (December 2nd-3rd, 2020, Italy).

Paolo A Ascierto, Carlo Bifulco, Fortunato Ciardiello, Sandra Demaria, Leisha A Emens, Robert Ferris, Silvia C Formenti, Jerome Galon, Samir N Khleif, Tomas Kirchhoff and 9 more

Open access · goldAbstract read
In one paragraph

Article in Journal of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 16 institutions in 3 countries.

Paolo A AsciertoDepartment of Melanoma, Cancer Immunotherapy and Innovative Therapy, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", Naples, Italy. paolo.ascierto@gmail.com.ORCID 0000-0002-8322-475X
Carlo BifulcoProvidence Cancer Center, Earle A. Chiles Research Institute, Portland, OR, USA.
Fortunato CiardielloMedical Oncology and Hematology Division, University "Luigi Vanvitelli", Naples, Italy.
Sandra DemariaDepartment of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
Leisha A EmensMagee Women's Hospital, Pittsburgh, PA, USA.
Robert FerrisUPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Silvia C FormentiWeill Cornell Medicine and Meyer Cancer Center, New York, NY, USA.
Jerome GalonINSERM, Laboratory of Integrative Cancer Immunology, Paris, France.
Samir N KhleifThe Loop Immuno Oncology Laboratory, Georgetown University Medical School, Washington, DC, USA.
Tomas KirchhoffPerlmutter Cancer Center, New York, NY, USA.
Jennifer McQuadeMelanoma Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA.
Kunle OdunsiUniversity of Chicago Medicine Comprehensive Cancer Center, Chicago, IL, USA.
Akash PatnaikSection of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, IL, USA.
Chrystal M PaulosWinship Cancer Institute at Emory University, Atlanta, GA, USA.
Janis M TaubeDepartment of Dermatology, Johns Hopkins University SOM, Baltimore, MD, USA.
John TimmermanDavid Geffen School of Medicine, UCLA Medical Center, Los Angeles, CA, USA.
Bernard A FoxEarle A. Chiles Research Institute, Robert W. Franz Cancer Research Center, Providence Cancer Institute, Portland, OR, USA.
Patrick HwuMoffitt Cancer Center, Tampa, FL, USA.
Igor PuzanovDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Cornell University · USProvidence Portland Medical Center · USUniversity of Chicago · USEmory University · USGeorgetown University · USInserm · FRIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITJohns Hopkins University · USMagee-Womens Hospital · USMoffitt Cancer Center · USNYU Langone’s Laura and Isaac Perlmutter Cancer CenterOlive View-UCLA Medical Center · USRoswell Park Comprehensive Cancer Center · USThe University of Texas MD Anderson Cancer Center · USUniversity of Campania "Luigi Vanvitelli" · ITUPMC Hillman Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Improved understanding of tumor immunology has enabled the development of therapies that harness the immune system and prevent immune escape. Numerous clinical trials and real-world experience has provided evidence of the potential for long-term survival with immunotherapy in various types of malignancy. Recurring observations with immuno-oncology agents include their potential for clinical application across a broad patient population with different tumor types, conventional and unconventional response patterns, durable responses, and immune-related adverse events. Despite the substantial achievements to date, a significant proportion of patients still fail to benefit from current immunotherapy options, and ongoing research is focused on transforming non-responders to responders through the development of novel treatments, new strategies to combination therapy, adjuvant and neoadjuvant approaches, and the identification of biomarkers of response. These topics were the focus of the virtual Immunotherapy Bridge (December 2nd-3rd, 2020), organized by the Fondazione Melanoma Onlus, Naples, Italy, in collaboration with the Society for Immunotherapy of Cancer and are summarised in this report.

Indexed as

Biomarkers, TumorMelanomaHumansImmunotherapyItalyNeoplasm Recurrence, LocalBiomarkers, TumorBiomarkersCheckpoint inhibitorsCombination therapyImmunotherapyTumor microenvironmentVaccine

Identifiers

PMID34078406
PMCPMC8173810
OpenAlexW3165836611

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.