ArticlePediatric rheumatology online journal2021
Streptococcal infection in childhood Henoch-Schönlein purpura: a 5-year retrospective study from a single tertiary medical center in China, 2015-2019.
Article in Pediatric rheumatology online journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- National recommendations for the management of children and young people with IgA vasculitis: a best available evidence, group agreement-based approach.Archives of disease in childhood · 2024Guideline
- Infectious triggers in IgA vasculitis in children: current evidence, causal attribution and immunopathogenic mechanisms.Rheumatology international · 2026Review
- Angioedema: a rare manifestation of Henoch-Schönlein purpura.BMJ case reports · 2026Article
- Demographic, Clinical, and Laboratory Characteristics of Pediatric IgA Vasculitis: A Retrospective Five-Year Single-Center Experience.Journal of clinical medicine · 2026Article
- Clinical efficacy and gut microbiota profiling by 16S rRNA sequencing in children with Henoch-Schönlein purpura treated with integrated Chinese and Western medicine.Frontiers in microbiology · 2026Article
- Oral microbiota and urinary system diseases: from mechanistic insights to clinical implications-a comprehensive review.Frontiers in dental medicine · 2026Review
- Clinical review of adult Henoch-Schönlein purpura and analysis of predictors related to gastrointestinal involvement.Frontiers in immunology · 2025Article
- Predicting renal damage in children with IgA vasculitis by machine learning.Pediatric nephrology (Berlin, Germany) · 2024Article
- Common Seasonal Pathogens and Epidemiology of Henoch-Schönlein Purpura Among Children.JAMA network open · 2024Article
- Revising the value of Antistreptolysin O titre in childhood and its interpretation in the diagnostic approach of rheumatic diseases.European journal of pediatrics · 2024Article
- Delayed diagnosis of abdominal Henoch-Schonlein purpura in children: A case report.World journal of clinical cases · 2023Article
- [Clinical characteristics, pathology, and prognosis of children with diffuse endocapillary proliferative Henoch-Schönlein purpura nephritis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023Article
- A case series on recurrent and persisting IgA vasculitis (Henoch Schonlein purpura) in children.Pediatric rheumatology online journal · 2023Article
- Risk factors associated with recurrence of Henoch-Schonlein purpura: a retrospective study.Frontiers in pediatrics · 2023Article
- Causal relationships between circulating inflammatory factors and IgA vasculitis: a bidirectional Mendelian randomization study.Frontiers in immunology · 2023Article
- Development and validation of a nomogram to predict recurrence in children with Henoch-Schönlein purpura.American journal of translational research · 2022Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe present study focuses on the associations of streptococcal infection with the clinical phenotypes, relapse/recurrence and renal involvement in Henoch-Schönlein purpura (HSP) children.
methodsTwo thousand seventy-four Chinese children with HSP were recruited from January 2015 to December 2019. Patients' histories associated with HSP onset were obtained by interviews and questionnaires. Laboratory data of urine tests, blood sample and infectious agents were collected. Renal biopsy was performed by the percutaneous technique.
results(1) Streptococcal infection was identified in 393 (18.9%) HSP patients, and served as the most frequent infectious trigger. (2) Among the 393 cases with streptococcal infection, 43.0% of them had arthritis/arthralgia, 32.1% had abdominal pain and 29.3% had renal involvement. (3) 26.1% of HSP patients relapsed or recurred more than 1 time within a 5-year observational period, and the relapse/recurrence rate in streptococcal infectious group was subjected to a 0.4-fold decrease as compared with the non-infectious group. (4) No significant differences in renal pathological damage were identified among the streptococcal infectious group, the other infectious group and the non-infectious group.
conclusionsStreptococcal infection is the most frequent trigger for childhood HSP and does not aggravate renal pathological damage; the possible elimination of streptococcal infection helps relieve the relapse/recurrence of HSP.
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