ArticleNutrition journal2021
Evaluation of the effect of vitamin D supplementation on spermatogram, seminal and serum levels of oxidative stress indices in asthenospermia infertile men: a study protocol for a triple-blind, randomized controlled trial.
Article in Nutrition journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Association between serum Vitamin D levels and sperm DNA fragmentation index in varicocele patients: a retrospective cohort study.Reproductive biology and endocrinology : RB&E · 2025Article
- Sperm metabolomic signatures of asthenozoospermia and teratozoospermia in Chinese reproductive-age men.Scientific reports · 2025Article
- Elucidating the chrononutrition patterns and sleep quality among subfertile patients with different vitamin D levels.Scientific reports · 2025Article
- Vitamin D in male sexual functions: unwrapping the sunshine hormone activities in erectile function and beyond.Frontiers in reproductive health · 2025Review
- The Influence of Lifestyle on Male Fertility in the Context of Insulin Resistance-Identification of Factors That Influence Semen Quality.Journal of clinical medicine · 2024Article
- Vitamin D and reproductive disorders: a comprehensive review with a focus on endometriosis.Reproductive health · 2024Review
- Effect of Vitamin D3 on some Antioxidant Parameters in Chilled Semen in Awassi Ram.Archives of Razi Institute · 2023Article
- Modulation ofAmerican journal of men's healthArticle
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is suggested that vitamin D may have a beneficial role in male reproduction. The male reproductive system is a target tissue for vitamin D. This study will aim to evaluate the effects of vitamin D supplementation on sperm parameters, seminal and serum levels of oxidative stress and serum endocrine factors in asthenospermia infertile men. METHODS/
designThis randomized, triple-blind, placebo-controlled clinical trial will be conducted on 86 infertile men with idiopathic asthenozoospermia (the mobility of sperm < 40% and rapid progressive sperm motility < 32%), with serum levels of vitamin D less than 30 ng / ml in the "Infertility Clinic of Ahvaz Jahad daneshgahi", Iran. MAIN OUTCOMES MEASURE (S): Demographic data, dietary intake, physical activity, sun exposure, anthropometric indices, serum and seminal levels of MDA (Malondialdehyde), 8-hydroxy-2- Dioxy Guanosine (8-OHDG), Total Antioxidant Capacity (TAC) and calcium, sperm DNA fragmentation index (DFI), serum 25-OHD, luteinizing hormone (LH), follicle-stimulating hormone (FSH), total testosterone (T), estradiol (E2), sex hormone-binding globulin (SHBG), free androgen index (FAI = T/SHBG. 100), T/LH and T/E2 ratios, prolactin (PRO), parathyroid hormone (PTH), osteocalcin (OCN), phosphorus and sperm parameters. DISCUSSION: The deficiency of vitamin D as an antioxidant is common all over the world. Numerous observational studies have shown a positive association between vitamin D levels and semen quality. However, few clinical studies have been conducted in this area. So considering with the high prevalence of this antioxidant deficiency specifically in infertile men, it seems that the supplementation of vitamin D in infertile men with insufficient levels or deficiency may improve the status of oxidative stress and thereby may affect sperm parameters and endocrine factors involved in male fertility.
trial registrationIran Clinical Trials Registry, ID: IRCT20151128025274N4 , registered on 28 March 2018.
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