Evidence map›Paper›PMID 34078264›Full record

ArticleBMC bioinformatics2021

FEGS: a novel feature extraction model for protein sequences and its applications.

Zengchao Mu, Ting Yu, Xiaoping Liu, Hongyu Zheng, Leyi Wei, Juntao Liu

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Article in BMC bioinformatics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

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17citing papers in PubMed
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3 · Its place in the literature

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17 citing papers in PubMed.

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  6. Overview and Prospects of DNA Sequence Visualization.International journal of molecular sciences · 2025
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4 · The record

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5 · Who and what money

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6 authors.

Zengchao Mu *School of Mathematics and Statistics, Shandong University, Weihai, 264209, China.
Ting Yu *Research Center for Mathematics and Interdisciplinary Sciences, Shandong University, Qingdao, 266237, China.
Xiaoping Liu *Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Beijing, China.
Hongyu ZhengDepartment of Radiation Oncology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China.
Leyi WeiSchool of Software, Shandong University, Jinan, China. weileyi@sdu.edu.cn.
Juntao LiuSchool of Mathematics and Statistics, Shandong University, Weihai, 264209, China. juntaosdu@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFeature extraction of protein sequences is widely used in various research areas related to protein analysis, such as protein similarity analysis and prediction of protein functions or interactions.

resultsIn this study, we introduce FEGS (Feature Extraction based on Graphical and Statistical features), a novel feature extraction model of protein sequences, by developing a new technique for graphical representation of protein sequences based on the physicochemical properties of amino acids and effectively employing the statistical features of protein sequences. By fusing the graphical and statistical features, FEGS transforms a protein sequence into a 578-dimensional numerical vector. When FEGS is applied to phylogenetic analysis on five protein sequence data sets, its performance is notably better than all of the other compared methods.

conclusionThe FEGS method is carefully designed, which is practically powerful for extracting features of protein sequences. The current version of FEGS is developed to be user-friendly and is expected to play a crucial role in the related studies of protein sequence analyses.

Indexed as

ProteinsSequence Analysis, ProteinAlgorithmsAmino AcidsAmino Acid SequencePhylogenyAmino AcidsProteinsFeature extractionGraphical representationPhysicochemical properties of amino acidsProtein similarity analysisStatistical features

Identifiers

PMID34078264
PMCPMC8172329

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