ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2021
Reliability of task-specific neuronal activation assessed with functional PET, ASL and BOLD imaging.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 33 citations in OpenAlex.
- Acute effects of selective serotonin reuptake inhibitors on cerebral glucose metabolism and blood flow.Translational psychiatry · 2026Trial
- Monash DaCRA fPET-fMRI: A dataset for comparison of radiotracer administration for high temporal resolution functional FDG-PET.GigaScience · 2022Trial
- Mapping dynamics in neuronal activation and molecular connectivity with functional PET.Frontiers in neuroscience · 2026Review
- Optimal filtering strategies for task-specific functional PET imaging.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
- Estimation of hypoperfused tissue volume in large vessel occlusions: pseudo-continuous arterial spin labeling versus dynamic susceptibility contrast perfusion-weighted imaging.Quantitative imaging in medicine and surgery · 2025Article
- Functional PET/MRI reveals active inhibition of neuronal activity during optogenetic activation of the nigrostriatal pathway.Science advances · 2024Article
- Real-time motion-enabling positron emission tomography of the brain of upright ambulatory humans.Communications medicine · 2024Article
- A more objective PD diagnostic model: integrating texture feature markers of cerebellar gray matter and white matter through machine learning.Frontiers in aging neuroscience · 2024Article
- Effect of Meditation on Brain Activity during an Attention Task: A Comparison Study of ASL and BOLD Task fMRI.Brain sciences · 2023Article
- Hyperperfusion of bilateral amygdala in patients with chronic migraine: an arterial spin-labeled magnetic resonance imaging study.The journal of headache and pain · 2023Article
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- Identification of resting-state networks using dynamic brain perfusion SPECT imaging: A fSPECT case report.Frontiers in human neuroscience · 2023Article
- Cerebral perfusion variance in new daily persistent headache and chronic migraine: an arterial spin-labeled MR imaging study.The journal of headache and pain · 2022Article
- Learning induces coordinated neuronal plasticity of metabolic demands and functional brain networks.Communications biology · 2022Article
- Periodic electroencephalographic discharges and epileptic spasms involve cortico-striatal-thalamic loops on Arterial Spin Labeling Magnetic Resonance Imaging.Brain communications · 2022Article
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12 authors at 2 institutions in 1 country.
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Abstract
Mapping the neuronal response during cognitive processing is of crucial importance to gain new insights into human brain function. BOLD imaging and ASL are established MRI methods in this endeavor. Recently, the novel approach of functional PET (fPET) was introduced, enabling absolute quantification of glucose metabolism at rest and during task execution in a single measurement. Here, we report test-retest reliability of fPET in direct comparison to BOLD imaging and ASL. Twenty healthy subjects underwent two PET/MRI measurements, providing estimates of glucose metabolism, cerebral blood flow (CBF) and blood oxygenation. A cognitive task was employed with different levels of difficulty requiring visual-motor coordination. Task-specific neuronal activation was robustly detected with all three imaging approaches. The highest reliability was obtained for glucose metabolism at rest. Although this dropped during task performance it was still comparable to that of CBF. In contrast, BOLD imaging yielded high performance only for qualitative spatial overlap of task effects but not for quantitative comparison. Hence, the combined assessment of fPET and ASL offers reliable and simultaneous absolute quantification of glucose metabolism and CBF at rest and task.
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