Evidence map›Paper›PMID 34078023›Full record

ArticleKidney research and clinical practice2021

Implications of oxidative stress in chronic kidney disease: a review on current concepts and therapies.

Sagar Verma, Priyanka Singh, Shiffali Khurana, Nirmal Kumar Ganguly, Ritushree Kukreti, Luciano Saso, Devinder Singh Rana, Vibha Taneja, Vinant Bhargava

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PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney research and clinical practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 1 pooled it
8.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.

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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Sagar VermaDepartment of Research, Sir Ganga Ram Hospital, New Delhi, India.
Priyanka SinghCSIR-Institute of Genomics and Integrative Biology, New Delhi, India.
Shiffali KhuranaDepartment of Research, Sir Ganga Ram Hospital, New Delhi, India.
Nirmal Kumar GangulyDepartment of Research, Sir Ganga Ram Hospital, New Delhi, India.
Ritushree KukretiCSIR-Institute of Genomics and Integrative Biology, New Delhi, India.
Luciano SasoDepartment of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy.
Devinder Singh RanaDepartment of Nephrology, Sir Ganga Ram Hospital, New Delhi, India.
Vibha TanejaDepartment of Research, Sir Ganga Ram Hospital, New Delhi, India.
Vinant BhargavaDepartment of Nephrology, Sir Ganga Ram Hospital, New Delhi, India.
Sir Ganga Ram Hospital · INInstitute of Genomics and Integrative Biology · INSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Moderate levels of endogenous reactive oxygen species (ROS) are important for various cellular activities, but high levels lead to toxicity and are associated with various diseases. Levels of ROS are maintained as a balance between oxidants and antioxidants. Accumulating data suggest that oxidative stress is a major factor in deterioration of renal function. In this review, we highlight the possible mechanism by which oxidative stress can lead to chronic kidney disease (CKD). This review also describes therapies that counter the effect of oxidative stress in CKD patients. Numerous factors such as upregulation of genes involved in oxidative phosphorylation and ROS generation, chronic inflammation, vitamin D deficiency, and a compromised antioxidant defense mechanism system cause progressive detrimental effects on renal function that eventually lead to loss of kidney function. Patients with renal dysfunction are highly susceptible to oxidative stress, as risk factors such as diabetes, renal hypertension, dietary restrictions, hemodialysis, and old age predispose them to increased levels of ROS. Biomolecular adducts (DNA, proteins, and lipids) formed due to reaction with ROS can be used to determine oxidative stress levels. Based on the strong correlation between oxidative stress and CKD, reversal of oxidative stress is being explored as a major therapeutic option. Xanthine oxidase inhibitors, dietary antioxidants, and other agents that scavenge free radicals are gaining interest as treatment modalities in CKD patients.

Indexed as

AntioxidantsChronic kidney diseaseHemodialysisOxidative stress

Identifiers

PMID34078023
PMCPMC8237115
OpenAlexW3154992383

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.