ArticleThrombosis and haemostasis2022
An Older Thrombus Delays Reperfusion after Mechanical Thrombectomy for Ischemic Stroke.
Article in Thrombosis and haemostasis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Thrombus Perviousness Is Associated With Differential Treatment Outcomes Following IVT and EVT in MeVO Stroke.Stroke · 2026Article
- Early- versus Late-Window Mechanical Thrombectomy for Isolated M2/M3 Middle Cerebral Artery Occlusions: 90-Day Outcomes and Procedural Characteristics in a Single-Center Cohort.Neuroradiology · 2026Article
- Detailed Analysis of Thrombus Composition and Endovascular Thrombectomy Efficiency in Ischemic Stroke Patients with Middle Cerebral Artery Occlusion Undergoing Thrombectomy.Journal of clinical medicine · 2025Article
- Programmable MRI contrast switching for spatiotemporal mapping of thrombus maturation via enzyme-directed nanoprobe reconfiguration.Nano convergence · 2025Article
- Transcriptome Analysis IdentifiedJournal of the American Heart Association · 2025Article
- Prediction of Occlusion Duration in Nonacute Intracranial Large Artery Through High-Resolution Vessel Wall Imaging.Journal of the American Heart Association · 2025Article
- Platelet Analysis in the Thrombus Plus Serum BNP for Detecting Clot-Related Atrial Fibrillation. Results From the ITACAT Multicentric Registry.Translational stroke research · 2025Article
- Artificial biomarker-based feedback-regulated personalized and precise thrombolysis with lower hemorrhagic risk.Science advances · 2025Article
- Thrombus Age in Ischemic Stroke With Atrial Fibrillation: Impact on Mechanical Thrombectomy.Stroke (Hoboken, N.J.) · 2025Article
- Predicting Recanalization Failure With Conventional Devices During Endovascular Treatment Related to Vessel Occlusion.Stroke (Hoboken, N.J.) · 2024Article
- X-ray Attenuating Vesicles with Neutrophil Extracellular Trap (NET) Specificity: Synthesis and Testing in a Model System.ACS omega · 2024Article
- Traditional Thrombus Composition and Related Endovascular Outcomes: Catching up with the Recent Evidence.Neurointervention · 2024Review
- Targeting Neutrophil Extracellular Traps for Stroke Prognosis: A Promising Path.Neurology international · 2023Review
- Aspiration thrombectomy with the Penumbra System for patients with stroke and late onset to treatment: a subset analysis of the COMPLETE registry.Frontiers in neurology · 2023Article
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Authors and funding
30 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThrombosis is a dynamic process, and a thrombus undergoes physical and biochemical changes that may alter its response to reperfusion therapy. This study assessed whether thrombus age influenced reperfusion quality and outcomes after mechanical thrombectomy for cerebral embolism.
methodsWe retrospectively evaluated 185 stroke patients and thrombi that were collected during mechanical thrombectomy at three stroke centers. Thrombi were pathologically classified as fresh or older based on their granulocytes' nuclear morphology and organization. Thrombus components were quantified, and the extent of NETosis (the process of neutrophil extracellular trap formation) was assessed using the density of citrullinated histone H3-positive cells. Baseline patient characteristics, thrombus features, endovascular procedures, and functional outcomes were compared according to thrombus age.
resultsFresh thrombi were acquired from 43 patients, and older thrombi were acquired from 142 patients. Older thrombi had a lower erythrocyte content (
conclusionAn older thrombus delays reperfusion after mechanical thrombectomy for ischemic stroke. Adding therapies targeting thrombus maturation may improve the efficacy of mechanical thrombectomy.
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