ArticleNeuron2021
Rapid suppression and sustained activation of distinct cortical regions for a delayed sensory-triggered motor response.
Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 107 citations in OpenAlex.
- Article
- Retrosplenial cortex enables context-dependent goal-directed sensorimotor transformation.eLife · 2026Article
- A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performance.bioRxiv : the preprint server for biology · 2026Article
- Anterior lateral motor cortex enables contextual decision-making via dynamic reconfiguration of local circuits.Cell reports · 2026Article
- Contextual gating of whisker-evoked responses by frontal cortex supports flexible decision making.Nature communications · 2026Article
- The role of transthalamic pathways in perception.Communications biology · 2026Review
- Cortex-wide characterization of decision-making neural dynamics during spatial navigation.Nature communications · 2026Article
- An intralayer microcircuit in the temporal association cortex underlies sensory-induced escape in mice.Nature communications · 2026Article
- A prefrontal cortex map based on single-neuron activity.Nature neuroscience · 2026Article
- Neural barcoding representing cortical spatiotemporal dynamics based on continuous-time Markov chains.Cell reports methods · 2026Article
- Article
- An adaptive and flexible role for primary sensory cortex.Nature neuroscience · 2026Review
- Article
- Subthalamic stimulation shifts brain network dynamics from extensive functional support to motor dominance in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Dissociable cortical contributions to impulse control during waiting.Science advances · 2025Article
- ALM enables contextual decision-making via dynamic reconfiguration of local circuits.bioRxiv : the preprint server for biology · 2025Article
- Whether or not to act is determined by distinct signals from motor thalamus and orbitofrontal cortex to secondary motor cortex.Nature communications · 2025Article
- Locomotion-dependent auditory gating to the parietal cortex guides multisensory decisions.Nature communications · 2025Article
- Perceptual choice and motor signals in mouse somatosensory cortex.bioRxiv : the preprint server for biology · 2024Article
- Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neuronal mechanisms generating a delayed motor response initiated by a sensory cue remain elusive. Here, we tracked the precise sequence of cortical activity in mice transforming a brief whisker stimulus into delayed licking using wide-field calcium imaging, multiregion high-density electrophysiology, and time-resolved optogenetic manipulation. Rapid activity evoked by whisker deflection acquired two prominent features for task performance: (1) an enhanced excitation of secondary whisker motor cortex, suggesting its important role connecting whisker sensory processing to lick motor planning; and (2) a transient reduction of activity in orofacial sensorimotor cortex, which contributed to suppressing premature licking. Subsequent widespread cortical activity during the delay period largely correlated with anticipatory movements, but when these were accounted for, a focal sustained activity remained in frontal cortex, which was causally essential for licking in the response period. Our results demonstrate key cortical nodes for motor plan generation and timely execution in delayed goal-directed licking.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.