ArticleCell reports2021
An acquired acyltransferase promotes Klebsiella pneumoniae ST258 respiratory infection.
Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- AnResearch square · 2026Article
- Molecular epidemiology of carbapenemase-carrying Klebsiella pneumoniae in China: Distribution of carbapenemase types, capsular serotypes, and virulence factors.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Decoding Host-Pathogen Dynamics inAntibiotics (Basel, Switzerland) · 2026Review
- How do immunometabolites shape bacterial infections?PLoS biology · 2026Article
- Emergence and regional evolution of Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae ST11 in China.BMC genomics · 2025Article
- Bloodstream infections: mechanisms of pathogenesis and opportunities for intervention.Nature reviews. Microbiology · 2025Review
- Genomic and immunocyte characterisation of bloodstream infection caused by Klebsiella pneumoniae.Annals of clinical microbiology and antimicrobials · 2024Article
- Lipid A modification of colistin-resistantInfection and immunity · 2024Article
- Molecular characteristics, fitness, and virulence of high-risk and non-high-risk clones of carbapenemase-producingMicrobiology spectrum · 2024Article
- Influence of NMolecules (Basel, Switzerland) · 2024Article
- Subinhibitory antibiotic concentrations promote the excision of a genomic island carried by the globally spread carbapenem-resistantMicrobial genomics · 2023Article
- Acetylation-dependent coupling between G6PD activity and apoptotic signaling.Nature communications · 2023Article
- Klebsiella pneumoniae causes bacteremia using factors that mediate tissue-specific fitness and resistance to oxidative stress.PLoS pathogens · 2023Article
- Immunometabolic control byImmunometabolism (Cobham, Surrey) · 2023Review
- Oral Administration ofMicroorganisms · 2023Article
- In vivo single-cell transcriptomics reveal Klebsiella pneumoniae skews lung macrophages to promote infection.EMBO molecular medicine · 2022Article
- The ADP-Heptose Biosynthesis Enzyme GmhB is a Conserved Gram-Negative Bacteremia Fitness Factor.Infection and immunity · 2022Article
- Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection.Cell metabolism · 2022Article
- Bacterial metabolism and pathogenesis intimate intertwining: time for metabolic modelling to come into action.Microbial biotechnology · 2022Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
Klebsiella pneumoniae ST258 is a human pathogen associated with poor outcomes worldwide. We identify a member of the acyltransferase superfamily 3 (atf3), enriched within the ST258 clade, that provides a major competitive advantage for the proliferation of these organisms in vivo. Comparison of a wild-type ST258 strain (KP35) and a Δatf3 isogenic mutant generated by CRISPR-Cas9 targeting reveals greater NADH:ubiquinone oxidoreductase transcription and ATP generation, fueled by increased glycolysis. The acquisition of atf3 induces changes in the bacterial acetylome, promoting lysine acetylation of multiple proteins involved in central metabolism, specifically Zwf (glucose-6 phosphate dehydrogenase). The atf3-mediated metabolic boost leads to greater consumption of glucose in the host airway and increased bacterial burden in the lung, independent of cytokine levels and immune cell recruitment. Acquisition of this acyltransferase enhances fitness of a K. pneumoniae ST258 isolate and may contribute to the success of this clonal complex as a healthcare-associated pathogen.
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