Evidence map›Paper›PMID 34077586›Full record

ArticleCancer science2021

Dhx15 regulates zebrafish definitive hematopoiesis through the unfolded protein response pathway.

Yuanhua Cai, Jing Wang, Daqing Jin, Qiao Liu, Xianglei Chen, Lili Pan, Yang Li, Xuechun Wang, Feng Qian, Jiucun Wang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Learning from Zebrafish Hematopoiesis.Advances in experimental medicine and biology · 2023
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Yuanhua CaiUnion Clinical Medical Colleges, Fujian Medical University, Fuzhou, China.
Jing WangUnion Clinical Medical Colleges, Fujian Medical University, Fuzhou, China.
Daqing JinShanghai Key Laboratory of Regulatory Biology, Institute of Molecular Medicine, East China Normal University School of Life Sciences, Shanghai, China.
Qiao LiuUnion Clinical Medical Colleges, Fujian Medical University, Fuzhou, China.
Xianglei ChenUnion Clinical Medical Colleges, Fujian Medical University, Fuzhou, China.
Lili PanUnion Clinical Medical Colleges, Fujian Medical University, Fuzhou, China.
Yang LiUnion Clinical Medical Colleges, Fujian Medical University, Fuzhou, China.
Xuechun WangUnion Clinical Medical Colleges, Fujian Medical University, Fuzhou, China.
Feng QianSchool of Life Sciences and Institutes of Biomedical Sciences, Ministry of Education Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, Fudan University, Shanghai, China.
Jiucun WangSchool of Life Sciences and Institutes of Biomedical Sciences, Ministry of Education Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, Fudan University, Shanghai, China.
Tao Peter ZhongShanghai Key Laboratory of Regulatory Biology, Institute of Molecular Medicine, East China Normal University School of Life Sciences, Shanghai, China.
Shaoyuan WangUnion Clinical Medical Colleges, Fujian Medical University, Fuzhou, China.ORCID https://orcid.org/0000-0001-7428-8682
Fujian Medical University · CNEast China Normal University · CNFudan University · CNVanderbilt University · US

Funding

Construction Project of Fujian Medical Center of Hematology 201704Fujian Province Health Education Joint Research Project 2016-2-07Fujian Provincial Department of Finance 2017-655National Natural Science Foundation of China 81270609National Natural Science Foundation of China 81470008National Natural Science Foundation of China 81500139National Natural Science Foundation of China 81770163The National and Fujian Provincial Key Clinical Specialty Discipline Construction Program 2011-1006The National and Fujian Provincial Key Clinical Specialty Discipline Construction Program 2012-149
6 · The paper itself

Abstract

Gene alterations are recognized as important events in acute myeloid leukemia (AML) progression. Studies on hematopoiesis of altered genes contribute to a better understanding on their roles in AML progression. Our previous work reported a DEAH box helicase 15 (DHX15) R222G mutation in AML patients, and we showed DHX15 overexpression is associated with poor prognosis in AML patients. In this work, we further study the role of dhx15 in zebrafish developmental hematopoiesis by generating dhx15

Indexed as

AnimalsAnimals, Genetically ModifiedApoptosisCell ProliferationDEAD-box RNA HelicasesGene Knockout TechniquesHematopoiesisHematopoietic Stem CellsHumansIn Situ HybridizationLeukemia, Myeloid, AcuteMutationRNA HelicasesUnfolded Protein ResponseZebrafishZebrafish ProteinsDEAD-box RNA HelicasesDHX15 protein, humanRNA HelicasesZebrafish Proteinsacute myeloid leukemiaDEAH box helicase 15hematopoiesisunfolded protein responsezebrafish

Identifiers

PMID34077586
PMCPMC8409414
OpenAlexW3164054647

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.