ArticlePloS one2021
Torque Teno Virus load in lung cancer patients correlates with age but not with tumor stage.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Analysis of Torquetenovirus DNA levels in NSCLC patients treated with immune checkpoint inhibitors.PloS one · 2026Article
- Torque Teno Virus: Lights and Shades.Viruses · 2025Review
- Study on the Molecular Prevalence and Genotypic Distribution of Torque Teno Virus in Iranian Hemodialysis Patients.BioMed research international · 2025Article
- Molecular characterization of plasma virome of hepatocellular carcinoma (HCC) patients.AMB Express · 2024Article
- The mysterious anelloviruses: investigating its role in human diseases.BMC microbiology · 2024Review
- [Surgery of old people-Thoracic surgery].Wiener klinisches Magazin : Beilage zur Wiener klinischen Wochenschrift · 2023Review
- Metagenomic insights into the plasma virome of Brazilian patients with prostate cancer.Molecular & cellular oncology · 2023Article
- Obesity is associated with a higher Torque Teno viral load compared to leanness.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTorque teno virus (TTV) is a ubiquitous non-pathogenic virus, which is suppressed in immunological healthy individuals but replicates in immune compromised patients. Thus, TTV load is a suitable biomarker for monitoring the immunosuppression also in lung transplant recipients. Since little is known about the changes of TTV load in lung cancer patients, we analyzed TTV plasma DNA levels in lung cancer patients and its perioperative changes after lung cancer surgery. MATERIAL AND
methodsPatients with lung cancer and non-malignant nodules as control group were included prospectively. TTV DNA levels were measured by quantiative PCR using DNA isolated from patients plasma and correlated with routine circulating biomarkers and clinicopathological variables.
results47 patients (early stage lung cancer n = 30, stage IV lung cancer n = 10, non-malignant nodules n = 7) were included. TTV DNA levels were not detected in seven patients (15%). There was no significant difference between the stage IV cases and the preoperative TTV plasma DNA levels in patients with early stage lung cancer or non-malignant nodules (p = 0.627). While gender, tumor stage and tumor histology showed no correlation with TTV load patients below 65 years of age had a significantly lower TTV load then older patients (p = 0.022). Regarding routine blood based biomarkers, LDH activity was significantly higher in patients with stage IV lung cancer (p = 0.043), however, TTV load showed no correlation with LDH activity, albumin, hemoglobin, CRP or WBC. Comparing the preoperative, postoperative and discharge day TTV load, no unequivocal pattern in the kinetics were.
conclusionOur study suggest that lung cancer has no stage dependent impact on TTV plasma DNA levels and confirms that elderly patients have a significantly higher TTV load. Furthermore, we found no uniform perioperative changes during early stage lung cancer resection on plasma TTV DNA levels.
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