Evidence map›Paper›PMID 34077415›Full record

ArticlePLoS biology2021

Intrinsic connectivity reveals functionally distinct cortico-hippocampal networks in the human brain.

Alexander J Barnett, Walter Reilly, Halle R Dimsdale-Zucker, Eda Mizrak, Zachariah Reagh, Charan Ranganath

Abstract read
In one paragraph

Article in PLoS biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  9. What episodic memory reveals about the default mode network.Current opinion in behavioral sciences · 2026
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  19. Prefrontal Default Mode Network Interactions with Posterior Hippocampus during Exploration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  20. Hippocampal-Cortical Networks Predict Conceptual versus Perceptually Guided Narrative Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alexander J BarnettCenter for Neuroscience, University of California at Davis, Davis, California, United States of America.ORCID 0000-0001-5891-7880
Walter ReillyCenter for Neuroscience, University of California at Davis, Davis, California, United States of America.
Halle R Dimsdale-ZuckerDepartment of Psychology, Columbia University, New York, New York, United States of America.ORCID 0000-0002-8611-111X
Eda MizrakCenter for Neuroscience, University of California at Davis, Davis, California, United States of America.
Zachariah ReaghCenter for Neuroscience, University of California at Davis, Davis, California, United States of America.
Charan RanganathCenter for Neuroscience, University of California at Davis, Davis, California, United States of America.

Funding

Neuroscience of Cognitive AgingT32AG050061 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DECARLI, CHARLES · 2016 to 2020
$869k
NIA NIH HHS T32 AG050061
6 · The paper itself

Abstract

Episodic memory depends on interactions between the hippocampus and interconnected neocortical regions. Here, using data-driven analyses of resting-state functional magnetic resonance imaging (fMRI) data, we identified the networks that interact with the hippocampus-the default mode network (DMN) and a "medial temporal network" (MTN) that included regions in the medial temporal lobe (MTL) and precuneus. We observed that the MTN plays a critical role in connecting the visual network to the DMN and hippocampus. The DMN could be further divided into 3 subnetworks: a "posterior medial" (PM) subnetwork comprised of posterior cingulate and lateral parietal cortices; an "anterior temporal" (AT) subnetwork comprised of regions in the temporopolar and dorsomedial prefrontal cortex; and a "medial prefrontal" (MP) subnetwork comprised of regions primarily in the medial prefrontal cortex (mPFC). These networks vary in their functional connectivity (FC) along the hippocampal long axis and represent different kinds of information during memory-guided decision-making. Finally, a Neurosynth meta-analysis of fMRI studies suggests new hypotheses regarding the functions of the MTN and DMN subnetworks, providing a framework to guide future research on the neural architecture of episodic memory.

Indexed as

HippocampusHumansMemoryNerve NetRestTask Performance and AnalysisTemporal LobeVisual Pathways

Identifiers

PMID34077415
PMCPMC8202937

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.