Evidence map›Paper›PMID 34077295›Full record

ArticleBioengineered2021

SP1-induced lncRNA ZFPM2 antisense RNA 1 (ZFPM2-AS1) aggravates glioma progression via the miR-515-5p/Superoxide dismutase 2 (SOD2) axis.

Yaxuan Zhang, Yin Zhang, Sen Wang, Qingquan Li, Boqiang Cao, Baosheng Huang, Tianlu Wang, Ruijuan Guo, Ning Liu

Open access · goldAbstract read
In one paragraph

Article in Bioengineered, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Unraveling the role of specificity protein 1 in gliomas: pathophysiology and clinical implications.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Yaxuan ZhangDepartment of Neurosurgery, Sir Run Run Hospital, Nanjing Medical University, China.
Yin ZhangDepartment of Neurosurgery, Sir Run Run Hospital, Nanjing Medical University, China.
Sen WangDepartment of Neurosurgery, Sir Run Run Hospital, Nanjing Medical University, China.
Qingquan LiDepartment of Neurosurgery, The Second Affiliated Hospital of Nanjing Medical University.
Boqiang CaoDepartment of Neurosurgery, Sir Run Run Hospital, Nanjing Medical University, China.
Baosheng HuangDepartment of Neurosurgery, Sir Run Run Hospital, Nanjing Medical University, China.
Tianlu WangDepartment of Neurosurgery, Sir Run Run Hospital, Nanjing Medical University, China.
Ruijuan GuoDepartment of ICU, The Affiliated Sir Run Run Hospital of Nanjing Medical University.
Ning LiuDepartment of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University.ORCID 0000-0002-5272-5420
Nanjing Medical University · CNJiangsu Province Hospital · CNSecond Affiliated Hospital of Nanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioma is a common life-threatening tumor with high malignancy and high invasiveness. LncRNA ZFPM2 antisense RNA 1 (ZFPM2-AS1) was confirmed to be implicated in numerous tumors, while its biological function and mechanism have not been thoroughly understood in glioma. The gene expression was measured by RT-qPCR. Cell proliferation, cell cycle, and cell apoptosis of glioma cells were validated by CCK-8, colony formation, flow cytometry and TUNEL assays. The effect of ZFPM2-AS1 on tumor growth was verified by

Indexed as

Brain NeoplasmsGliomaAnimalsCell Line, TumorDisease ProgressionHumansMaleMiceMice, NudeMicroRNAsRNA, Long NoncodingSp1 Transcription FactorSuperoxide DismutaseSuperoxide Dismutase 2MicroRNAsMIRN515 microRNA, humanRNA, Long NoncodingSP1 protein, humanSp1 Transcription FactorSuperoxide DismutaseSuperoxide Dismutase 2gliomamiR-515-5pSOD2SP1ZFPM2-AS1

Identifiers

PMID34077295
PMCPMC8806534
OpenAlexW3164541000

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.