Evidence map›Paper›PMID 34077272›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2021

Effect of chronic alcohol exposure on gut vitamin B7 uptake: involvement of epigenetic mechanisms and effect of alcohol metabolites.

Kalidas Ramamoorthy, Subrata Sabui, Padmanabhan Srinivasan, Saleh Al-Juburi, Quang Pham, Brian D Chu, Rita D Simoes, James M Fleckenstein, Hamid M Said

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Benefits and risks of hair, skin, and nail supplements in older adults.International journal of women's dermatology · 2025
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Kalidas RamamoorthyDepartment of Physiology/Biophysics, University of California, Irvine, California.
Subrata SabuiDepartment of Physiology/Biophysics, University of California, Irvine, California.
Padmanabhan SrinivasanDepartment of Physiology/Biophysics, University of California, Irvine, California.
Saleh Al-JuburiDepartment of Physiology/Biophysics, University of California, Irvine, California.
Quang PhamDepartment of Physiology/Biophysics, University of California, Irvine, California.
Brian D ChuDepartment of Physiology/Biophysics, University of California, Irvine, California.
Rita D SimoesDepartment of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri.
James M FleckensteinDepartment of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri.
Hamid M SaidDepartment of Physiology/Biophysics, University of California, Irvine, California.
University of California, Irvine · USWashington University in St. Louis · USLong Beach Medical Center · US

Funding

Novel Antigen Identification for an Enterotoxigenic E. coli VaccineR01AI089894 · NIAID · WASHINGTON UNIVERSITY · PI Zachary T. Berndsen, James Michael Fleckenstein · 2010 to 2026
$7.4M
INTESTINAL VITAMIN H UPTAKE--MOLECULAR/CELL REGULATIONR01DK058057 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI SAID, HAMID M · 2000 to 2019
$6.8M
Physiology/Pathophysiology of Vitamin B1 Transport in Pancreatic Acinar CellsR01AA018071 · NIAAA · UNIVERSITY OF CALIFORNIA-IRVINE · PI SAID, HAMID M · 2009 to 2023
$6.3M
Vitamin B1 (thiamin) transport in Alzheimer’s Disease: Role of microRNAs in regulating level of expression of its transporters (SLC19A2 & SLC19A3) in human brain cells and effect of hypoxiaR01DK056061 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI SAID, HAMID M · 1999 to 2024
$5.0M
Mechanism/Regulation of Intestinal Thiamin UptakeR37DK056061 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI SAID, HAMID M · 2009 to 2018
$3.6M
Molecular Microbiology of Enterotoxigenic E. coli Pathogen-Host InteractionsR01AI126887 · NIAID · WASHINGTON UNIVERSITY · PI FLECKENSTEIN, JAMES MICHAEL · 2016 to 2020
$1.6M
Physiological and Pathological Aspects of Intestinal Vitamin B2 AbsorptionI01BX001142 · VA · VETERANS HEALTH ADMINISTRATION · PI HAMID M SAID · 2011 to 2026
–
Molecular Pathogenesis of Enterotoxigenic Escherichia coli InfectionsI01BX004825 · VA · ST. LOUIS VA MEDICAL CENTER · PI FLECKENSTEIN, JAMES MICHAEL · 2020 to 2024
–
BLRD VA I01 BX001142BLRD VA I01 BX004825HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI126887HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK56061HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK58057HHS | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA) AA018071NIAAA NIH HHS R01 AA018071NIAID NIH HHS R01 AI089894NIAID NIH HHS R01 AI126887NIDDK NIH HHS R01 DK056061NIDDK NIH HHS R01 DK058057NIDDK NIH HHS R37 DK056061
6 · The paper itself

Abstract

Vitamin B7 (biotin) is essential for normal health and its deficiency/suboptimal levels occur in a variety of conditions including chronic alcoholism. Mammals, including humans, obtain biotin from diet and gut-microbiota via absorption along the intestinal tract. The absorption process is carrier mediated and involves the sodium-dependent multivitamin transporter (SMVT;

Indexed as

DNA MethylationEpigenesis, GeneticAcetaldehydeAnimalsBiotinCaco-2 CellsCells, CulturedEthanolHumansIntestinal MucosaKruppel-Like Factor 4Kruppel-Like Transcription FactorsMiceMice, Inbred C57BLOleic AcidsPalmitic AcidsAcetaldehydeBiotinbiotin transporterEthanolethyl oleateethyl palmitateKLF4 protein, humanKlf4 protein, mouseKruppel-Like Factor 4Kruppel-Like Transcription FactorsOleic AcidsPalmitic AcidsSymportersalcohol/alcohol metabolitesbiotinepigeneticshuman enteroids/colonoidsintestine/colonic uptake

Identifiers

PMID34077272
PMCPMC8410103
OpenAlexW3164118707

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.