Evidence map›Paper›PMID 34076945›Full record

ArticleAngewandte Chemie (International ed. in English)2021

An Alkyne-Metathesis-Based Approach to the Synthesis of the Anti-Malarial Macrodiolide Samroiyotmycin A.

Ektoras Yiannakas, Mark I Grimes, James T Whitelegge, Alois Fürstner, Alison N Hulme

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Reactivity of a dAngewandte Chemie (International ed. in English) · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Iron-Catalyzed trans-Hydrostannation of Terminal Alkynes.Angewandte Chemie (International ed. in English) · 2025
    Article
  7. Total Synthesis of Tosyl-Samroiyotmycin A and Its Biological Profiling.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Total Synthesis of the Allenic Macrolide (+)-Archangiumide.Journal of the American Chemical Society · 2024
    Article
  12. Article
  13. Total Synthesis of Njaoamine C by Concurrent Macrocycle Formation.Journal of the American Chemical Society · 2023
    Article
  14. Article
  15. Article
  16. The Ascent of Alkyne Metathesis to Strategy-Level Status.Journal of the American Chemical Society · 2021
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ektoras YiannakasSchool of Chemistry, University of Edinburgh, Joseph Black Building, David Brewster Road, Edinburgh, EH9 3FJ, UK.ORCID 0000-0002-4580-5238
Mark I GrimesSchool of Chemistry, University of Edinburgh, Joseph Black Building, David Brewster Road, Edinburgh, EH9 3FJ, UK.ORCID 0000-0001-7655-8156
James T WhiteleggeSchool of Chemistry, University of Edinburgh, Joseph Black Building, David Brewster Road, Edinburgh, EH9 3FJ, UK.ORCID 0000-0002-9235-4716
Alois FürstnerDepartment of Organometallic Chemistry, Max-Planck-Institut für Kohlenforschung, 45470, Mülheim/Ruhr, Germany.ORCID 0000-0003-0098-3417
Alison N HulmeSchool of Chemistry, University of Edinburgh, Joseph Black Building, David Brewster Road, Edinburgh, EH9 3FJ, UK.ORCID 0000-0002-4619-1506

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the first total synthesis of samroiyotmycin A (1), a C

Indexed as

AlkynesAntimalarialsMolecular StructureAlkynesAntimalarialsalkyneshydrostannationmetathesisnatural productstotal synthesis

Identifiers

PMID34076945
PMCPMC8456858

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.