ReviewChemistry (Weinheim an der Bergstrasse, Germany)2021
The Deuterated "Magic Methyl" Group: A Guide to Site-Selective Trideuteromethyl Incorporation and Labeling by Using CD
Review in Chemistry (Weinheim an der Bergstrasse, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- A Riboflavin-Derived Flavinium Salt Mediates Chemoselective Methylation Reactions.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Electricity-driven site-selective deuteration of pharmaceuticals.Chemical science · 2026Article
- Expected and Unexpected "Guests" at the Active Site of Human Orotidine 5'-Monophosphate Decarboxylase.Biochemistry · 2025Article
- Electroreductive amination of carboxylic acids by cobalt catalysis.Nature communications · 2025Article
- Methylations with methanol via bioinspired catalytic C-O bond cleavage.Nature communications · 2025Article
- Synthesis, preclinical assessment, and first-in-human study of [European journal of nuclear medicine and molecular imaging · 2025Article
- Catalytic undirected methylation of unactivated C(spNature communications · 2024Article
- Leveraging long-lived arenium ions in superacid for meta-selective methylation.Nature communications · 2024Article
- Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4.Journal of medicinal chemistry · 2024Article
- Synthesis of Deuterated Endochin-Like Quinolones.Journal of labelled compounds & radiopharmaceuticals · 2024Article
- Three-Component Cross-Electrophile Coupling: Regioselective Electrochemical Dialkylation of Alkenes.Journal of the American Chemical Society · 2023Article
- Deuterium in drug discovery: progress, opportunities and challenges.Nature reviews. Drug discovery · 2023Review
- Ruthenium-Catalyzed Monoselective C-H Methylation andJACS Au · 2022Article
- Enantioselective alkylative cross-coupling of unactivated aromatic C-O electrophiles.Nature communications · 2022Article
- Modifications of the Triaminoaryl Metabophore of Flupirtine and Retigabine Aimed at Avoiding Quinone Diimine Formation.ACS omega · 2022Article
- The Deuterated "Magic Methyl" Group: A Guide to Site-Selective Trideuteromethyl Incorporation and Labeling by Using CDChemistry (Weinheim an der Bergstrasse, Germany) · 2021Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In the field of medicinal chemistry, the precise installation of a trideuteromethyl group is gaining ever-increasing attention. Site-selective incorporation of the deuterated "magic methyl" group can provide profound pharmacological benefits and can be considered an important tool for drug optimization and development. This review provides a structured overview, according to trideuteromethylation reagent, of currently established methods for site-selective trideuteromethylation of carbon atoms. In addition to CD
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.