Evidence map›Paper›PMID 34076892›Full record

Trial reportCancer2021

The PREPARE for Your Care program increases advance care planning engagement among diverse older adults with cancer.

Sarah S Nouri, Deborah E Barnes, Ying Shi, Aiesha M Volow, Nikita Shirsat, Anne L Kinderman, Heather A Harris, Rebecca L Sudore

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
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  5. Article
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  8. Advance Care Planning in Multicultural Communities: A Document Analysis of Resources to Support Healthcare Staff and Consumers in Australia.Health expectations : an international journal of public participation in health care and health policy · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sarah S NouriDivision of Palliative Medicine, Department of Medicine, University of California San Francisco, San Francisco, California.ORCID 0000-0001-7163-0366
Deborah E BarnesDepartment of Psychiatry, University of California San Francisco, San Francisco, California.
Ying ShiSan Francisco Veterans Affairs Health Care System, San Francisco, California.
Aiesha M VolowDivision of Geriatrics, Department of Medicine, University of California San Francisco, San Francisco, California.
Nikita ShirsatDivision of Geriatrics, Department of Medicine, University of California San Francisco, San Francisco, California.
Anne L KindermanSan Francisco General Hospital and Trauma Center, San Francisco, California.
Heather A HarrisSan Francisco General Hospital and Trauma Center, San Francisco, California.
Rebecca L SudoreSan Francisco Veterans Affairs Health Care System, San Francisco, California.
University of California, San Francisco · USSan Francisco General Hospital · US

Funding

Improving advance care planning for seniors at risk for Alzheimers disease and related dementias and their caregiversR01AG045043 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI SUDORE, REBECCA L · 2013 to 2017
$3.2M
Mentoring Researchers in Advance Care Planning for Underrepresented Older Adults at Risk for Alzheimer’s Disease and Related Dementias and Their CaregiversK24AG054415 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI REBECCA L SUDORE · 2017 to 2026
$1.7M
NIA NIH HHS K24 AG054415NIA NIH HHS R01 AG045043NIH HHS T32HP19025Patient-Centered Outcomes Research Institute CDR-1306-01500
6 · The paper itself

Abstract

backgroundAdvance care planning (ACP) is low among older adults with cancer. In a secondary analysis of randomized trial data, the authors compared the efficacy of the PREPARE for Your Care (PREPARE) website plus an easy-to-read advance directive (AD) with an AD only among older adults with and without cancer.

methodsSafety net, primary care patients in San Francisco were included if they were 55 years old or older, were English- or Spanish-speaking, and had 2 or more chronic conditions. The authors determined cancer diagnoses by using International Classification of Diseases, Ninth Revision/Tenth Revision codes. The primary outcome was new ACP documentation in the medical record at 15 months; the secondary outcomes were self-reported ACP engagement, ease of use, satisfaction, and depression/anxiety. The authors used mixed effects logistic and linear regression adjusted for prior ACP, health literacy, and clinician, including a cancer interaction term.

resultsOf 986 participants, 220 (22%) had cancer. The mean age was 63 years (SD, 6 years), 61% were women, 81% were of a minority race/ethnicity, 45% were Spanish-speaking, 39% had limited health literacy, and 27% had prior ACP. New ACP documentation was higher in the PREPARE arm versus the AD-only arm among participants with cancer (62% vs 43%; P = .01) and without cancer (38% vs 28%; P = .01), as was ACP engagement in both arms (P < .001), with no interactions by cancer. Ease of use and satisfaction were high, and depression/anxiety was low, with no differences by study arm or by cancer/no cancer.

conclusionsPREPARE plus an easy-to-read AD increased ACP documentation and engagement among diverse older adults with cancer more than an AD alone, with no increase in depression or anxiety between study arms or by cancer. PREPARE may help to decrease ACP disparities among patients with cancer. LAY SUMMARY: Advance care planning (ACP) is the process of sharing values, goals, and preferences for medical care, but engagement in ACP is low among older adults with cancer. Among 986 English- and Spanish-speaking older adults from a safety net hospital, an interactive, multimedia, web-based ACP program (PREPARE for Your Care at https://prepareforyourcare.org/) plus an easy-to-read advance directive increased ACP documentation and engagement more than an advance directive alone. There were no differences in this increase in ACP between older adults with cancer and older adults without cancer. Also, engaging in ACP did not result in increased depression or anxiety.

Indexed as

Advance Care PlanningHealth LiteracyNeoplasmsAdvance DirectivesAgedChronic DiseaseFemaleHumansMaleMiddle Agedadvance care planninghealth care disparitiessafety net providersvulnerable populations

Identifiers

PMID34076892
PMCPMC8711568
OpenAlexW3165648772

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.