ReviewHead and neck pathology2022
Carcinoma Cuniculatum of the Oral Cavity: A Series of 6 Cases and Review of Literature.
Review in Head and neck pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Genetic Landscape of Oral Carcinoma Cuniculatum and its Histological Mimics.Head and neck pathology · 2026Article
- Diagnostic challenges for a case of maxillary carcinoma cuniculatum in the setting of human immunodeficiency virus: a case report.Oral and maxillofacial surgery · 2026Review
- Intraosseous Atypical Verrucopapillary Epithelial Proliferation with Verrucous Carcinoma Features Evolving from a Keratinizing Odontogenic Cyst: Report of an Uncommon Variant and Review of the Literature.Head and neck pathology · 2026Review
- Article
- A rare intersection: Oral carcinoma cuniculatum in the context of Down syndrome.Journal of oral and maxillofacial pathology : JOMFP · 2025Article
- Treatment of recurrent oral carcinoma cuniculatum with immune checkpoint blockade: A case report and literature review.Oral oncology reports · 2025Article
- Infrequent Histopathologic Subtypes of Oral Squamous Cell Carcinoma: A Case Series with Emphasis on Histopathologic Characteristics.Journal of dentistry (Shiraz, Iran) · 2025Article
- Aggressive Oral Carcinoma Cuniculatum Presenting with Recurrence and Metastasis: A Case Report.Journal of maxillofacial and oral surgery · 2025Article
- Esophageal Carcinoma Cuniculatum.Annals of thoracic surgery short reports · 2024Article
- Gingival Carcinoma Cuniculatum: A Case Series of Seven Cases with Emphasis on Immunohistochemical and Histochemical Features.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Oral Carcinoma Cuniculatum: A Variant of Squamous cell Carcinoma with Unique Histological Characteristics and a Diagnostic Challenge.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- Article
- Carcinoma Cuniculatum of the Maxilla Arising From Oroantral Fistula: A Report of an Extremely Rare Case.Cureus · 2023Article
- Esophageal carcinoma cuniculatum: a narrative review to understand this rare and commonly misdiagnosed variant of well-differentiated esophageal squamous cell carcinoma.Translational gastroenterology and hepatology · 2023Review
- Carcinoma Cuniculatum of the Maxilla Mimicking Nonhealing Extraction Sockets at the Right Molar Region - An Interesting Case.Eplasty · 2023Article
- Oral carcinoma cuniculatum: an unacquainted entity with diagnostic challenges-a case report.Journal of the Egyptian National Cancer Institute · 2022Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carcinoma cuniculatum (CC) is a rare variant of squamous cell carcinoma (SCC) that is characterized by minimal cytologic atypia and a unique deeply infiltrative growth pattern resembling rabbit burrows (cuniculi). With less than 75 cases reported in the head and neck, the clinical and pathologic spectrum of this entity remains poorly understood. A retrospective review of the clinical and pathologic features of archival cases of oral CC was performed. A total of six cases of oral CC were identified. Age ranged from 25-77 years; the male-to-female ratio was 5:1. All patients had a long-standing history of tobacco and betel-quid consumption. The tumors were distributed in the gingivobuccal sulcus (n = 2), the tongue (n = 2), buccal mucosa (n = 1), and the palate (n = 1). Histology in all cases typically revealed a tumor composed of well-differentiated squamous epithelium, devoid of atypia, lining deeply infiltrative, large-sized, branching, keratin-filled cavities, resembling rabbit-burrows. Dense lymphocytic infiltrates and discharging micro-abscesses were regular features. Underlying bone invasion and lymph node metastasis were observed in 1 patient. One patient with a tongue tumor developed locoregional recurrence at 10 months while none developed distant metastasis. Oral CC is a rare and under-recognized variant of SCC with locally aggressive behavior. Lack of familiarity with this variant exacerbated by the absence of cytologic anaplasia makes CC susceptible to multiple negative biopsies and erroneous diagnoses. Awareness of this clinicopathologic entity is essential to allow its accurate diagnosis and optimal management.
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