Evidence map›Paper›PMID 34076790›Full record

ArticleMolecular biology reports2021

Circulating miRNA 27a and miRNA150-5p; a noninvasive approach to endometrial carcinoma.

Rasha Abdelmawla Ghazala, Eman Ahmed El-Attar, Ziad Sami Abouzeid

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
0.8field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
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  3. Pooled it
  4. Review
  5. MiR-205-5p and MiR-222-3p as Potential Biomarkers of Endometrial Cancer.International journal of molecular sciences · 2025
    Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Rasha Abdelmawla GhazalaMedical Biochemistry Department, Faculty of Medicine, Alexandria University, Champollion street, Al Mesallah Sharq, Al Attarin, Alexandria, Egypt.ORCID http://orcid.org/0000-0002-4281-3718
Eman Ahmed El-AttarChemical Pathology Department, Medical Research Institute, Alexandria University, 165 El-Horreya Avenue, El- Hadra, Alexandria, 21561, Egypt. emanelattar2005@yahoo.com.ORCID http://orcid.org/0000-0003-1335-2673
Ziad Sami AbouzeidDepartment of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University, Champollion street, Al Mesallah Sharq, Al Attarin, Alexandria, Egypt.ORCID http://orcid.org/0000-0002-7787-8757
Alexandria University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The search for novel non-invasive biomarkers such as epigenetic molecular markers is new hope for common and burdensome cancers. We aim to assess serum expression of miRNA 27a and miRNA150-5p in endometrial cancer patients. Serum was drawn for 36 un-intervened endometrial cancer patients scheduled for hysterectomy and 35 controls. miRNA 27a and miRNA150-5p were measured by real time reverse transcription polymerase chain reaction. Significant overexpression of both miRNA in patients (p < 0.001). At cutoffs 0.2872 & > 1.02, miRNA 27a showed 100% sensitivity, specificity, positive and negative predictive values. miRNA150-5p showed 88.89% sensitivity, 100% specificity, 100% positive and 78.9% negative predictive values. Areas under curve were 1.0 for miRNA 27a, 0.982 for miRNA 150 performing much better than Ca125. miRNA 27a was significantly associated with type I endometroid endometrial cancer. Conclusion: miRNA 27a and miRNA-150-5P can be suggested as promising biomarkers of endometrial cancer possibly part of a miRNA panel for management.

Indexed as

Gene ExpressionGene Expression Regulation, NeoplasticAdultAgedArea Under CurveBiomarkers, TumorCA-125 AntigenCase-Control StudiesCirculating MicroRNAEndometrial NeoplasmsFemaleHumansMicroRNAsMiddle AgedPredictive Value of TestsReal-Time Polymerase Chain ReactionBiomarkers, TumorCA-125 AntigenCirculating MicroRNAMicroRNAsMIR150, humanMIRN27 microRNA, humanCa125Endometrial carcinomaEpigeneticsmiRNA15-5pmiRNA 27a

Identifiers

PMID34076790
OpenAlexW3164618438

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.