SynthesisSurgical endoscopy2021
Endoscopic techniques to reduce recurrence rates after colorectal EMR: systematic review and meta-analysis.
Synthesis in Surgical endoscopy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Endoscopic full-thickness resection versus endoscopic submucosal dissection for colorectal lesions: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- Thermal ablation of margins for recurrence prevention after endoscopic mucosal resection: a systematic review and meta-analysis.Surgical endoscopy · 2025Pooled it
- Approaches to assessing completeness of colorectal polyp resections in clinical practice: a systematic scoping review.Endoscopy · 2026Article
- Structured Cap-assisted Margin Assessment Reduces Residual Neoplasia after Colorectal Polypectomy: A Prospective Multicentre Proof-of-Concept Study.Endoscopy international open · 2026Article
- Case Report: Successful endoscopic resection of a huge rectal tumor extending to the dentate line and associated with a diverticulum by endoscopic submucosal dissection.Frontiers in medicine · 2026Article
- Navigating the Terrain of Post-Polypectomy Surveillance: Charting the Complex Landscape of Guidelines and Recurrence Risks.Canadian journal of gastroenterology & hepatology · 2026Review
- Development and validation of a machine learning model for predicting 3-year recurrence of adenomatous colorectal polyps after EMR: a multicenter study.Frontiers in oncology · 2026Article
- Prevention and treatment of recurrence after endoscopic resection of large non-pedunculated colorectal polyps.World journal of gastrointestinal endoscopy · 2025Review
- Comparison of three electrosurgical modes for endoscopic mucosal resection of 10- to 20-mm colorectal polyps: Randomized controlled trial.Endoscopy international open · 2025Article
- Algorithmic approach for endoscopic management of colorectal polyps: an up-to-date review.Gastroenterology and hepatology from bed to bench · 2025Review
- Endoscopic mucosal resection defect inspection for predicting recurrences: International image-based survey.Endoscopy international open · 2025Article
- Dual Channel Endoscopic Mucosal Resection.Clinics in colon and rectal surgery · 2024Review
- Efficacy and Safety of Thermal Ablation after Endoscopic Mucosal Resection: A Systematic Review and Network Meta-Analysis.Journal of clinical medicine · 2024Review
- New Score to Predict Recurrence After Resection of Non-pedunculated Colonic Polyps: Critical Appraisal and External Validation.Digestive diseases and sciences · 2023Article
- Hybrid Argon Plasma Coagulation for Barrett's Esophagus and for Colonic Mucosal Resection-A Systematic Review and Meta-Analysis.Biomedicines · 2023Review
- Analysis of risk factors for postoperative bleeding and polyp recurrence in adolescents with gastric polyps treated with endoscopic mucosal resection: a retrospective cohort study.Translational pediatrics · 2023Article
- Post-EMR for colorectal polyps, thermal ablation of defects reduces adenoma recurrence: A meta-analysis.Endoscopy international open · 2022Review
- Thermal ablation of mucosal defect margins to prevent local recurrence of large colorectal polyps: a systematic review and meta-analysis.Endoscopy international open · 2022Review
- Endoscopic Mucosal Resection: Best Practices for Gastrointestinal Endoscopists.Gastroenterology & hepatology · 2022Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundColorectal endoscopic mucosal resection (EMR) is an effective, safe, and minimally invasive treatment for large lateral spreading and sessile polyps. The reported high recurrence rate of approximately 20% is however one of the major drawbacks. Several endoscopic interventions have been suggested to reduce recurrence rates. We conducted a systematic review and meta-analysis to assess the efficacy of endoscopic interventions targeting the EMR margin to reduce recurrence rates.
methodsWe searched in PubMed and Ovid for studies comparing recurrence rates after interventions targeting the EMR margin with standard EMR. The primary outcome was the recurrence rate at the first surveillance colonoscopy (SC1) assessed histologically or macroscopically. For the meta-analysis, risk ratios (RRs) were calculated and pooled using a random effects model. The secondary outcome was post-procedural complication rates.
resultsSix studies with a total of 1335 lesions were included in the meta-analysis. The techniques performed in the intervention group targeting the resection margin were argon plasma coagulation, snare tip soft coagulation, extended EMR, and precutting EMR. The interventions reduced the adenoma recurrence rate with more than 50%, resulting in a pooled RR of 0.37 (95% CI 0.18, 0.76) comparing the intervention group with the control groups. Overall post-procedural complication rates did not increase significantly in the intervention arm (RR 1.30; 95% CI 0.65, 2.58).
conclusionInterventions targeting the EMR margin decrease recurrence rates and may not result in more complications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.