Evidence map›Paper›PMID 34076727›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2022

Risk factors of lymphovascular invasion in hypopharyngeal squamous cell carcinoma and its influence on prognosis.

Gao Gang, Chen Xinwei, Chen LiXiao, Zhang Yu, Zhang Cheng, Dong Pin

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Gao GangDepartment of Otorhinolaryngology Head and Neck Surgery, Shanghai General Hospital of Nanjing Medical University, Shanghai, 200080, China.
Chen XinweiDepartment of Otorhinolaryngology Head and Neck Surgery, Shanghai General Hospital of Nanjing Medical University, Shanghai, 200080, China.
Chen LiXiaoDepartment of Otorhinolaryngology Head and Neck Surgery, Shanghai General Hospital of Nanjing Medical University, Shanghai, 200080, China.
Zhang YuDepartment of Otorhinolaryngology Head and Neck Surgery, Shanghai General Hospital of Nanjing Medical University, Shanghai, 200080, China.
Zhang ChengDepartment of Otorhinolaryngology Head and Neck Surgery, Shanghai General Hospital of Nanjing Medical University, Shanghai, 200080, China.
Dong PinDepartment of Otorhinolaryngology Head and Neck Surgery, Shanghai General Hospital of Nanjing Medical University, Shanghai, 200080, China. dongpin64@aliyun.com.ORCID http://orcid.org/0000-0003-2944-4679
Shanghai Medical College of Fudan University · CN

Funding

Clinical Research Plan of SHDC Grant NO. 16CR2029B
6 · The paper itself

Abstract

purposeLymphatic vascular invasion (LVI) is a poor prognostic factor for hypopharyngeal squamous cell carcinoma (HPSCC), but the risk factors of LVI and its relationship with clinicopathological of HPSCC remain unclear. This study aims to explore these issues.

methodsWe retrospectively analyzed the clinicopathological data of 170 patients with HPSCC from January 2011 to December 2015. The relationship between LVI and clinicopathologic was analyzed by Chi-square test or Fisher's exact test. The risk factors of LVI were examined using a logistic regression model, while risk factors of survival rate were carried out using the Cox regression model.

resultsLVI occurred in 59 cases (34.7%). In multivariate analysis, T3-4 stage (HR = 2.877; 95% CI: 1.379-6.004; p = 0.005), N2-3 stage (HR = 2.325; 95% CI: 1.120-4.824; p = 0.024), and poor differentiation (HR = 2.983; 95% CI: 1.229-7.242; p = 0.016) were independent risk factors for LVI; positive LVI was an independent risk factor for local recurrence (HR = 2.488; 95% CI: 1.150-5.383; p = 0.021), poor 5-year OS (HR = 0.375; 95% CI: 0.232-0.606; p < 0.000), DSS (HR = 0.374; 95% CI: 0.235-0.595; p < 0.000), and DFS (HR = 0.454; 95% CI:0.254-0.813; p = 0.008).

conclusionT3-4 stage, N2-3 stage and poor differentiation are independent risk factors for LVI of HPSCC; LVI increases the local recurrence and regional recurrence rate, and decreases 5-year OS, DFS and DSS of HPSCC.

Indexed as

Head and Neck NeoplasmsHumansNeoplasm InvasivenessNeoplasm StagingPrognosisRetrospective StudiesRisk FactorsSquamous Cell Carcinoma of Head and NeckClinicopathologicHypopharyngeal squamous cell carcinomaLymphovascular invasionPrognosisRisk factors

Identifiers

PMID34076727
OpenAlexW3165723642

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.