Evidence map›Paper›PMID 34076706›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2021

Insight into the longitudinal relationship between chronic subclinical inflammation and obesity from adolescence to early adulthood: a dual trajectory analysis.

Darren Beales, Amber Beynon, Angela Jacques, Anne Smith, Flavia Cicuttini, Leon Straker

Abstract read
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In one paragraph

Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Darren BealesCurtin School of Allied Health, Curtin University, GPO Box U1987, Perth, WA, 6845, Australia. D.Beales@curtin.edu.au.ORCID http://orcid.org/0000-0002-7176-4644
Amber BeynonCollege of Science, Health, Engineering and Education, Murdoch University, 90 South Street, Murdoch, WA, 6150, Australia.
Angela JacquesCurtin School of Allied Health, Curtin University, GPO Box U1987, Perth, WA, 6845, Australia.
Anne SmithCurtin School of Allied Health, Curtin University, GPO Box U1987, Perth, WA, 6845, Australia.
Flavia CicuttiniDepartment of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Level 1, 553 St Kilda Rd, Melbourne, VIC, 3004, Australia.
Leon StrakerCurtin School of Allied Health, Curtin University, GPO Box U1987, Perth, WA, 6845, Australia.

Funding

Curtin University of Technology Core FundingDepartment of Health, Government of Western Australia G06302Edith Cowan University Core FundingMurdock University Core FundingNational Health and Medical Research Council (Data Collect 14, 17, 20, 22 follow-ups (211912, 003209, 403981, 323200, 353514, 1021105, 1027449, 1044840 and 1021858))Raine Medical Research Foundation Core FundingSafe Work Australia 20 year follow-upTelethon Kids Institute Core FundingUniversity of Notre Dame Australia Core FundingUniversity of Western Australia Core FundingWomen and Infants Research Foundation Core Funding
6 · The paper itself

Abstract

OBJECTIVES AND

designThis study aimed to understand the longitudinal relationship between C-reactive protein (CRP) and body mass index (BMI) from adolescence to early adulthood.

methodsCRP and BMI were collected from participants of the Raine Study Gen2 at 14-, 17-, 20- and 22-year follow-ups (n = 1312). A dual trajectory analysis was conducted to assess the association between CRP and BMI trajectories, providing conditional probabilities of membership of CRP trajectory membership given BMI trajectory membership. Best model fit was assessed by systematically fitting two to eight trajectory groups with linear and quadratic terms and comparing models according to the Bayesian Information Criterion statistic.

resultsThe three CRP trajectories were; "stable-low" (71.0%), "low-to-high" (13.8%) and "stable-high" (15.2%). Participants in a "high-increasing" BMI trajectory had a higher probability of being in the "stable-high" CRP trajectory (60.4% of participants). In contrast, individuals in the "medium-increasing" BMI trajectory did not have a significantly increased probability of being in the "stable-high" CRP trajectory.

conclusionsThese findings support that chronic sub-clinical inflammation is present through adolescence into early adulthood in some individuals. Targeting chronic sub-clinical inflammation though obesity prevention strategies may be important for improving future health outcomes.

Indexed as

AdolescentAdultBody Mass IndexChronic DiseaseC-Reactive ProteinFemaleHumansInflammationLongitudinal StudiesMaleObesityYoung AdultC-Reactive ProteinBody mass indexC-reactive proteinDual trajectory modellingSub-clinical inflammationThe Raine Study

Identifiers

PMID34076706

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.