Evidence map›Paper›PMID 34076594›Full record

ArticleActa crystallographica. Section D, Structural biology2021

Structure of human factor VIIa-soluble tissue factor with calcium, magnesium and rubidium.

Kanagasabai Vadivel, Amy E Schmidt, Duilio Cascio, Kaillathe Padmanabhan, Sriram Krishnaswamy, Hans Brandstetter, S Paul Bajaj

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta crystallographica. Section D, Structural biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Kanagasabai VadivelDepartment of Orthopaedic Surgery, University of California, Los Angeles, CA 90095, USA.
Amy E SchmidtDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA.
Duilio CascioDOE Institute for Genomics and Proteomics, University of California, Los Angeles, CA 90095, USA.
Kaillathe PadmanabhanDepartment of Biochemistry, Michigan State University, East Lansing, MI 48824, USA.
Sriram KrishnaswamyDivision of Hematology, The Children's Hospital of Philadelphia University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Hans BrandstetterDepartment of Biosciences, University of Salzburg, 5020 Salzburg, Austria.
S Paul BajajDepartment of Orthopaedic Surgery, University of California, Los Angeles, CA 90095, USA.
University of California, Los Angeles · USMichigan State University · USUniversity of Pennsylvania · USUniversity of Rochester Medical Center · USUniversity of Salzburg · AT

Funding

Translating Mechanistic Insights into Intrinsic Xase FunctionP01HL139420 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI BRUCE ALAN SULLENGER · 2018 to 2026
$22.4M
Molecular and Structural Recognition in Factor VIIa Induced CoagulationR01HL141850 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VADIVEL, KANAGASABAI · 2018 to 2021
$1.6M
Austrian Science Fund W1213NHLBI NIH HHS P01 HL139420NHLBI NIH HHS P01HL139420NHLBI NIH HHS R01 HL141850NHLBI NIH HHS R01HL141850
6 · The paper itself

Abstract

Coagulation factor VIIa (FVIIa) consists of a γ-carboxyglutamic acid (GLA) domain, two epidermal growth factor-like (EGF) domains and a protease domain. FVIIa binds three Mg

Indexed as

Factor VIIaBinding SitesCalciumHumansMagnesiumProtein BindingProtein DomainsRecombinant ProteinsRubidiumStructure-Activity RelationshipCalciumFactor VIIaMagnesiumrecombinant FVIIaRecombinant ProteinsRubidiumblood coagulation factor VIIacalciummagnesiumrubidiumsodium

Identifiers

PMID34076594
PMCPMC8171065
OpenAlexW3160440352

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.