Evidence map›Paper›PMID 34076576›Full record

ArticleeLife2021

Translation inhibitory elements from

Fatima Alghoul, Schaeffer Laure, Gilbert Eriani, Franck Martin

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. CriticalNAR genomics and bioinformatics · 2024
    Article
  6. Article
  7. Article
  8. Evolutionarily conserved inhibitory uORFs sensitizeProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Fatima AlghoulInstitut de Biologie Moléculaire et Cellulaire, "Architecture et Réactivité de l'ARN" CNRS UPR9002, Université de Strasbourg, Strasbourg, France.ORCID 0000-0003-1934-9483
Schaeffer LaureInstitut de Biologie Moléculaire et Cellulaire, "Architecture et Réactivité de l'ARN" CNRS UPR9002, Université de Strasbourg, Strasbourg, France.
Gilbert ErianiInstitut de Biologie Moléculaire et Cellulaire, "Architecture et Réactivité de l'ARN" CNRS UPR9002, Université de Strasbourg, Strasbourg, France.
Franck MartinInstitut de Biologie Moléculaire et Cellulaire, "Architecture et Réactivité de l'ARN" CNRS UPR9002, Université de Strasbourg, Strasbourg, France.ORCID 0000-0001-9724-4025
Centre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During embryogenesis, Hox mRNA translation is tightly regulated by a sophisticated molecular mechanism that combines two RNA regulons located in their 5'UTR. First, an internal ribosome entry site (IRES) enables cap-independent translation. The second regulon is a translation inhibitory element or TIE, which ensures concomitant cap-dependent translation inhibition. In this study, we deciphered the molecular mechanisms of mouse

Indexed as

Open Reading FramesProtein Biosynthesis5' Untranslated RegionsAnimalsCodon, TerminatorEukaryotic Initiation Factor-2Gene Expression Regulation, DevelopmentalHEK293 CellsHomeodomain ProteinsHumansInternal Ribosome Entry SitesNucleic Acid ConformationRabbitsRibosomesRNA CapsRNA, Messenger5' Untranslated RegionsCodon, TerminatorEukaryotic Initiation Factor-2Homeodomain ProteinsHoxa11 protein, mouseHoxa3 protein, mouseInternal Ribosome Entry SitesRNA CapsRNA, Messengerbiochemistrycell biologychemical biologyhox mRNAhumanmouseribosomeTIEtranslationuORF

Identifiers

PMID34076576
PMCPMC8172242
OpenAlexW3165562827

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.