Evidence map›Paper›PMID 34076483›Full record

ArticleJournal of virology2021

NAP1L1 and NAP1L4 Binding to Hypervariable Domain of Chikungunya Virus nsP3 Protein Is Bivalent and Requires Phosphorylation.

Francisco Dominguez, Nikita Shiliaev, Tetyana Lukash, Peter Agback, Oksana Palchevska, Joseph R Gould, Chetan D Meshram, Peter E Prevelige, Todd J Green, Tatiana Agback and 2 more

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Francisco DominguezDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Nikita ShiliaevDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Tetyana LukashDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Peter AgbackDepartment of Molecular Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Oksana PalchevskaDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Joseph R GouldDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Chetan D MeshramDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Peter E PreveligeDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Todd J GreenDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Tatiana AgbackDepartment of Molecular Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Elena I FrolovaDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Ilya FrolovDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
University of Alabama at Birmingham · USSwedish University of Agricultural Sciences · SE

Funding

Mechanistic role of ns2 protein in evasion of innate immune response by alphavirusesR01AI133159 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FROLOVA, ELENA I · 2017 to 2021
$3.0M
Alphavirus nsP3 protein: roles of intrinsically disordered region in virus replication and pathogenesisR01AI118867 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FROLOVA, ELENA I · 2015 to 2019
$1.8M
Mechanistic understanding of SH3 domain-containing protein function in alphavirus replicationR21AI146969 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FROLOV, ILYA V. · 2019 to 2020
$401k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI133159HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R21AI146969NIAID NIH HHS R01 AI118867NIAID NIH HHS R01 AI133159NIAID NIH HHS R21 AI146969Swedish Foundation for Strategic Research ITM17-0218
6 · The paper itself

Abstract

Chikungunya virus (CHIKV) is one of the most pathogenic members of the

Indexed as

AnimalsBinding SitesCasein Kinase IIChikungunya virusDNA-Binding ProteinsHost-Pathogen InteractionsMiceMutationNIH 3T3 CellsNuclear ProteinsNucleosome Assembly Protein 1PhosphorylationProtein BindingProtein Interaction Domains and MotifsViral Nonstructural ProteinsVirus ReplicationCasein Kinase IIDNA-Binding ProteinsNap1l1 protein, mouseNap1l4 protein, mousensp3 protein, alphavirusNuclear ProteinsNucleosome Assembly Protein 1Viral Nonstructural Proteinsalphaviruschikungunya virusCK2 kinaseintrinsically disordered proteinsNAP1L1NAP1L4nsP3protein phosphorylationviral pathogenesisviral replication

Identifiers

PMID34076483
PMCPMC8312869
OpenAlexW3164681743

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.