Evidence map›Paper›PMID 34076426›Full record

ArticleACS chemical neuroscience2021

Cooperativity of α-Synuclein Binding to Lipid Membranes.

Katarzyna Makasewicz, Stefan Wennmalm, Björn Stenqvist, Marco Fornasier, Alexandra Andersson, Peter Jönsson, Sara Linse, Emma Sparr

Open access · hybridAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Global kinetic model of lipid-inducedProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Review
  9. Review
  10. Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Morphology-Dependent Interactions between α-Synuclein Monomers and Fibrils.International journal of molecular sciences · 2023
    Article
  17. α-Synuclein Interaction with Lipid Bilayer Discs.Langmuir : the ACS journal of surfaces and colloids · 2022
    Article
  18. A Palette of Fluorescent AInternational journal of molecular sciences · 2022
    Article
  19. QRB discovery · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Katarzyna MakasewiczDivision of Physical Chemistry, Department of Chemistry, Lund University, P.O. Box 124, SE-22100 Lund, Sweden.ORCID 0000-0001-7224-5750
Stefan WennmalmDepartment of Applied Physics, Biophysics Group, SciLifeLab, Royal Institute of Technology-KTH, 171 65 Solna, Sweden.
Björn StenqvistDivision of Physical Chemistry, Department of Chemistry, Lund University, P.O. Box 124, SE-22100 Lund, Sweden.ORCID 0000-0002-9099-0663
Marco FornasierDivision of Physical Chemistry, Department of Chemistry, Lund University, P.O. Box 124, SE-22100 Lund, Sweden.
Alexandra AnderssonDivision of Physical Chemistry, Department of Chemistry, Lund University, P.O. Box 124, SE-22100 Lund, Sweden.
Peter JönssonDivision of Physical Chemistry, Department of Chemistry, Lund University, P.O. Box 124, SE-22100 Lund, Sweden.ORCID 0000-0003-2994-8017
Sara LinseDivision of Biochemistry and Structural Biology, Department of Chemistry, Lund University, SE-22100 Lund, Sweden.ORCID 0000-0001-9629-7109
Emma SparrDivision of Physical Chemistry, Department of Chemistry, Lund University, P.O. Box 124, SE-22100 Lund, Sweden.ORCID 0000-0001-8343-9657
Lund University · SEScience for Life Laboratory · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cooperative binding is a key feature of metabolic pathways, signaling, and transport processes. It provides tight regulation over a narrow concentration interval of a ligand, thus enabling switching to be triggered by small concentration variations. The data presented in this work reveal strong positive cooperativity of α-synuclein binding to phospholipid membranes. Fluorescence cross-correlation spectroscopy, confocal microscopy, and

Indexed as

alpha-SynucleinLipid BilayersPhospholipidsProtein BindingSpectrometry, FluorescenceUnilamellar Liposomesalpha-SynucleinLipid BilayersPhospholipidsUnilamellar LiposomesAdair equationCooperative bindingfluorescence correlation spectroscopyhomotropic allosterylipid membraneα-synuclein

Identifiers

PMID34076426
PMCPMC8291482
OpenAlexW3165580512

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.