ArticleCancer medicine2021
A modifiable risk factors atlas of lung cancer: A Mendelian randomization study.
Article in Cancer medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 88 citations in OpenAlex.
- The effectiveness of concurrent training in lung cancer survivors: a systematic review.Translational lung cancer research · 2026Review
- Sedentary behaviour and cancer risk: a World Cancer Research Fund International Global Cancer Update Programme (CUP Global) systematic literature review and meta-analysis.medRxiv : the preprint server for health sciences · 2026Article
- Investigating the causal role of sleep disorders in anorexia nervosa and obsessive-compulsive disorder: a bidirectional Mendelian randomization study.Eating and weight disorders : EWD · 2026Article
- Lung Cancer Risk Factors Beyond Smoking in Ethiopia: A Multicenter Matched Case-Control Study.Cancers · 2026Article
- Distinct roles of chronotype, daytime napping, and sleep duration in biological and functional aging: a univariable and multivariable Mendelian randomization study.Clinical epigenetics · 2026Article
- The relationship between autoimmune diseases and temporomandibular disorders: A study combined with the GEO database.Medicine · 2025Article
- Exploring the causal link between childhood maltreatment and asthma: a Mendelian randomization study.European journal of psychotraumatology · 2025Article
- Childhood maltreatment and mental health: causal links to depression, anxiety, non-fatal self-harm, suicide attempts, and PTSD.European journal of psychotraumatology · 2025Article
- Common sleep characteristics and the risk of common perinatal complications and adverse outcomes: a multi-sample, bidirectional Mendelian randomization study.BMC pregnancy and childbirth · 2025Article
- A phenome-wide Mendelian randomization analysis reveals the genetical associations of myocardial infarction, angina pectoris and Alzheimer's disease with lung cancer.Scientific reports · 2025Article
- Risk Factors and Prevention of Cancer and CVDs: A Chicken and Egg Situation.Journal of clinical medicine · 2025Review
- Fat-soluble Vitamins and Lung Cancer: Where We Are?Recent patents on anti-cancer drug discovery · 2025Review
- The association between metabolic syndrome and lung cancer risk: a Mendelian randomization study.Scientific reports · 2024Article
- Branched-chain amino acids and risk of lung cancer: insights from mendelian randomization and NHANES III.Journal of thoracic disease · 2024Article
- Impact of childhood maltreatment on aging: a comprehensive Mendelian randomization analysis of multiple age-related biomarkers.Clinical epigenetics · 2024Article
- Factors Influencing the Lung Cancer Incidence in China: A Meta-Analysis.Florence Nightingale journal of nursing · 2024Article
- Socioeconomic traits and the risk of Barrett's esophagus and gastroesophageal reflux disease: A Mendelian randomization study.World journal of gastrointestinal oncology · 2024Article
- Different effects of 24 dietary intakes on gastroesophageal reflux disease: A mendelian randomization.World journal of clinical cases · 2024Article
- Iron status and sarcopenia-related traits: a bi-directional Mendelian randomization study.Scientific reports · 2024Article
- Associations between breakfast skipping and outcomes in neuropsychiatric disorders, cognitive performance, and frailty: a Mendelian randomization study.BMC psychiatry · 2024Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThere has been no study systematically assessing the causal effects of putative modifiable risk factors on lung cancer. In this study, we aimed to construct a modifiable risk factors atlas of lung cancer by using the two-sample Mendelian randomization framework.
methodsWe included 46 modifiable risk factors identified in previous studies. Traits with p-value smaller than 0.05 were considered as suggestive risk factors. While the Bonferroni corrected p-value for significant risk factors was set to be 8.33 × 10
resultsIn this two-sample Mendelian randomization analysis, we found that higher socioeconomic status was significantly correlated with lower risk of lung cancer, including years of schooling, college or university degree, and household income. While cigarettes smoked per day, time spent watching TV, polyunsaturated fatty acids, docosapentaenoic acid, eicosapentaenoic acid, and arachidonic acid in blood were significantly associated with higher risk of lung cancer. Suggestive risk factors for lung cancer were found to be serum vitamin A1, copper in blood, docosahexaenoic acid in blood, and body fat percentage.
conclusionsThis study provided the first Mendelian randomization assessment of the causality between previously reported risk factors and lung cancer risk. Several modifiable targets, concerning socioeconomic status, lifestyle, dietary, and obesity, should be taken into consideration for the development of primary prevention strategies for lung cancer.
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