Evidence map›Paper›PMID 34076314›Full record

ArticleJournal of veterinary internal medicine2021

Association of markers of endothelial activation and dysfunction with occurrence and outcome of pulmonary hemorrhage in dogs with leptospirosis.

Franziska Sonderegger, Alice Nentwig, Ariane Schweighauser, Thierry Francey, Eliane Marti, Jelena Mirkovitch, Simone Schuller

Open access · goldAbstract readObservational Study, Veterinary
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Anemia in Dogs with Acute Kidney Injury.Veterinary sciences · 2024
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Franziska SondereggerDepartment Clinical Veterinary Medicine, Vetsuisse Faculty University of Bern, Bern, Switzerland.
Alice NentwigEnnetSee Klinik, Hünenberg, Switzerland.
Ariane SchweighauserDepartment Clinical Veterinary Medicine, Vetsuisse Faculty University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0001-9296-4509
Thierry FranceyDepartment Clinical Veterinary Medicine, Vetsuisse Faculty University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0002-6693-5365
Eliane MartiDepartment of Clinical Research and Veterinary Public Health (DCR-VPH), Vetsuisse Faculty University of Bern, Bern, Switzerland.
Jelena MirkovitchDepartment of Clinical Research and Veterinary Public Health (DCR-VPH), Vetsuisse Faculty University of Bern, Bern, Switzerland.
Simone SchullerDepartment Clinical Veterinary Medicine, Vetsuisse Faculty University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0002-7316-4423
University of Bern · CHKlinik Rosenberg · DE

Funding

Commission for Veterinary specialization of the Vetsuisse Faculty University of Bern
6 · The paper itself

Abstract

backgroundEndothelial dysfunction might contribute to the development of leptospiral pulmonary hemorrhage syndrome (LPHS). HYPOTHESIS: Serum concentrations of markers of endothelial activation and dysfunction are higher in dogs with leptospirosis and correlate with the occurrence of LPHS and a higher case fatality rate. ANIMALS: Clinically healthy dogs (n = 31; 10/31 dogs confirmed healthy based on no detected abnormalities on blood work), dogs with leptospirosis with LPHS (n = 17) and without LPHS (n = 15), dogs with acute kidney injury not due to leptospirosis (AKI-nL, n = 34).

methodsObservational study. Serum concentrations of soluble intercellular adhesion molecule 1 (sICAM-1), vascular endothelial growth factor (VEGF), and angiopoietin-2 (Ang-2) at admission were compared between groups. Correlations with outcome and the accuracy to predict LPHS were examined.

resultsSoluble intercellular adhesion molecule (sICAM-1), VEGF, and Ang-2 concentrations were higher in dogs with AKI-nL (sICAM-1 34.7 ng/mL, interquartile range [IQR] = 24.4-75.5; VEGF 43.1 pg/mL, IQR = 12.3-79.2; Ang-2 8.5 ng/mL, IQR = 6.2-12.3), leptospirosis without LPHS (sICAM-1 45.1 ng/mL, IQR = 30.6-59.0; VEGF 32.4 pg/mL, IQR = 12.5-62.6; Ang-2 9.6 ng/mL, IQR = 6.9-19.3), and LPHS (sICAM-1 69.7 ng/mL, IQR = 42.1-89.1; VEGF 51.8 pg/mL, IQR = 26.3-96.7; Ang-2 8.0 ng/mL, IQR = 5.6-12.2) compared to controls (P < .001). In dogs with leptospirosis, VEGF and sICAM-1 were higher in nonsurvivors (sICAM-1 89.4 ng/mL, IQR = 76.5-101.0; VEGF 117.0 pg/mL, IQR = 90.3-232.4) than survivors (P = .004) and sICAM-1 predicted the development of LPHS.

conclusionsSoluble intercellular adhesion molecule 1, VEGF, and Ang-2 do not discriminate leptospirosis from AKI-nL. In dogs with leptospirosis, sICAM-1 and VEGF predict outcome and sICAM-1 might identify dogs at risk for LPHS.

Indexed as

Dog DiseasesLeptospiraLeptospirosisLung DiseasesAnimalsBiomarkersDogsHemorrhageIntercellular Adhesion Molecule-1Vascular Endothelial Growth Factor ABiomarkersIntercellular Adhesion Molecule-1Vascular Endothelial Growth Factor Aacute kidney injurybleedingcanineendothelial markerLeptospirarespiratory

Identifiers

PMID34076314
PMCPMC8295707
OpenAlexW3164176688

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.