Evidence map›Paper›PMID 34075876›Full record

ArticleeLife2021

Repression by the

Alexander R Leydon, Wei Wang, Hardik P Gala, Sabrina Gilmour, Samuel Juarez-Solis, Mollye L Zahler, Joseph E Zemke, Ning Zheng, Jennifer L Nemhauser

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 66 citations in OpenAlex.

  1. Article
  2. Review
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  4. CONSERVATION AND DIVERGENCE WITHIN THEbioRxiv : the preprint server for biology · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Mechanisms of auxin action in plant growth and development.Nature reviews. Molecular cell biology · 2025
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Alexander R LeydonDepartment of Biology, University of Washington, Seattle, United States.ORCID 0000-0003-3034-1482
Wei WangDepartment of Pharmacology, Seattle, United States.
Hardik P GalaDepartment of Biology, University of Washington, Seattle, United States.
Sabrina GilmourDepartment of Biology, University of Washington, Seattle, United States.
Samuel Juarez-SolisDepartment of Biology, University of Washington, Seattle, United States.
Mollye L ZahlerDepartment of Biology, University of Washington, Seattle, United States.
Joseph E ZemkeDepartment of Biology, University of Washington, Seattle, United States.
Ning ZhengDepartment of Pharmacology, Seattle, United States.
Jennifer L NemhauserDepartment of Biology, University of Washington, Seattle, United States.ORCID 0000-0002-8909-735X
University of Washington · USHoward Hughes Medical Institute · USSeattle University · US

Funding

Control of protein degradation dynamics in the auxin responseR01GM107084 · NIGMS · UNIVERSITY OF WASHINGTON · PI NEMHAUSER, JENNIFER L · 2014 to 2022
$2.4M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM107084
6 · The paper itself

Abstract

The plant corepressor TOPLESS (TPL) is recruited to a large number of loci that are selectively induced in response to developmental or environmental cues, yet the mechanisms by which it inhibits expression in the absence of these stimuli are poorly understood. Previously, we had used the N-terminus of

Indexed as

ArabidopsisArabidopsis ProteinsCo-Repressor ProteinsGene Expression Regulation, FungalGene Expression Regulation, PlantMediator ComplexModels, MolecularNuclear ProteinsPlants, Genetically ModifiedProtein BindingProtein Conformation, alpha-HelicalProtein Interaction Domains and MotifsRepressor ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsStructure-Activity RelationshipArabidopsis ProteinsAt1g15750 protein, ArabidopsisCo-Repressor ProteinsMediator ComplexNuclear ProteinsNUT2 protein, S cerevisiaeRepressor ProteinsSaccharomyces cerevisiae ProteinsTUP1 protein, S cerevisiaeA. thalianachromosomescorepressorsgene expressionmediatorplant biologyS. cerevisiaeTOPLESStranscriptional repression

Identifiers

PMID34075876
PMCPMC8203292
OpenAlexW3164106901

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.