Evidence map›Paper›PMID 34075808›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2021

Interferon γ neutralization reduces blood pressure, uterine artery resistance index, and placental oxidative stress in placental ischemic rats.

Olivia K Travis, Geilda A Tardo, Chelsea Giachelli, Shani Siddiq, Henry T Nguyen, Madison T Crosby, Tyler D Johnson, Andrea K Brown, George W Booz, Alex N Smith and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Dark Sweet Cherry (Nutrients · 2023
    Trial
  3. IL-33 Signaling Inhibition Leads to a Preeclampsia-Like Phenotype in Pregnant Rats.American journal of reproductive immunology (New York, N.Y. : 1989) · 2024
    Article
  4. Review
  5. NLRP3 inhibition improves maternal hypertension, inflammation, and vascular dysfunction in response to placental ischemia.American journal of physiology. Regulatory, integrative and comparative physiology · 2023
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Olivia K TravisDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.ORCID 0000-0001-7392-9054
Geilda A TardoDepartment of Emergency Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
Chelsea GiachelliDepartment of Emergency Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
Shani SiddiqDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Henry T NguyenDepartment of Emergency Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
Madison T CrosbyDepartment of Emergency Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
Tyler D JohnsonDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Andrea K BrownDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
George W BoozDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Alex N SmithDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Jan Michael WilliamsDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Denise C CorneliusDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.ORCID 0000-0002-6730-6499
University of Mississippi Medical Center · US

Funding

Hypertension, Inflammation, and Vascular FunctionR01HL151407 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI CORNELIUS, DENISE CRESHUN · 2020 to 2024
$1.9M
Mechanisms involved in the early development of renal disease associated with prepubertal obesityR01DK109133 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI WILLIAMS, JAN MICHAEL · 2017 to 2021
$1.7M
Hypertension and InflammationR00HL130456 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI CORNELIUS, DENISE CRESHUN · 2017 to 2019
$747k
A Role for Natural Killer Cells in the Development of Intrauterine Growth Restriction and Hypertension During PregnancyF31HL149257 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI TRAVIS, OLIVIA KRISTELL · 2020 to 2021
$49k
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) F31HL149257HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R00HL130456HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL151407HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK109133NHLBI NIH HHS F31 HL149257NHLBI NIH HHS R00 HL130456NHLBI NIH HHS R01 HL151407NIDDK NIH HHS R01 DK109133
6 · The paper itself

Abstract

Preeclampsia (PE) is characterized by maternal hypertension, intrauterine growth restriction, and increased cytolytic natural killer cells (cNKs), which secrete interferon γ (IFNγ). However, the precise role of IFNγ in contributing to PE pathophysiology remains unclear. Using the reduced uterine perfusion pressure (RUPP) rat model of placental ischemia, we tested the hypothesis that neutralization of IFNγ in RUPPs will decrease placental reactive oxygen species (ROS) and improve vascular function resulting in decreased MAP and improved fetal growth. On

Indexed as

Angiogenic ProteinsAnimalsAntibodies, MonoclonalArterial PressureDisease Models, AnimalFemaleFetal Growth RetardationInterferon-gammaIschemiaKiller Cells, NaturalOxidative StressPlacentaPlacental CirculationPre-EclampsiaPregnancyRatsAngiogenic ProteinsAntibodies, MonoclonalInterferon-gammaReactive Oxygen Speciesinterferon γpreeclampsiareactive oxygen speciessoluble Fms-like tyrosine kinase-1

Identifiers

PMID34075808
PMCPMC8409917
OpenAlexW3164571428

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.