Observational studyJournal of the American Heart Association2021
Extent of Coronary Artery Disease in Patients With Stenotic Bicuspid Versus Tricuspid Aortic Valves.
Observational study in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Bicuspid aortic valve stenosis is characterized by increased angiogenesis, inflammation, and a higher valvular-to-systemic calcification ratio than tricuspid aortic valve stenosis.Basic research in cardiology · 2026Article
- Establishing reference values for aortic dimensions in the general Indian population and implications for global standards.Indian journal of thoracic and cardiovascular surgery · 2026Article
- Aortic root replacement for bicuspid aortic valve dysfunction does not impair survival rates.Journal of cardiothoracic surgery · 2024Article
- The Prevalence of Coronary Artery Disease in Bicuspid Aortic Valve Patients: An Overview of the Literature.Aorta (Stamford, Conn.) · 2023Article
- The role of transforming growth factor beta in bicuspid aortic valve aortopathy.Indian journal of thoracic and cardiovascular surgery · 2023Article
- Thoracic aortic atherosclerosis in patients with a bicuspid aortic valve; a case-control study.BMC cardiovascular disorders · 2023Article
- Commentary: Transforming growth factor serum concentrations in patients with proven non-syndromic aortopathy.Frontiers in cardiovascular medicine · 2023Article
- Thoracic aortopathy in Marfan syndrome overlaps with mechanisms seen in bicuspid aortic valve disease.Frontiers in cardiovascular medicine · 2023Article
- Are Thoracic Aortic Aneurysm Patients at Increased Risk for Cardiovascular Diseases?Journal of clinical medicine · 2022Article
- Normal and abnormal development of the aortic valve and ascending aortic wall: a comprehensive overview of the embryology and pathology of the bicuspid aortic valve.Annals of cardiothoracic surgery · 2022Review
- Are acute type A aortic dissections atherosclerotic?Frontiers in cardiovascular medicine · 2022Article
- Risk for acquired coronary artery disease in genetic vs. congenital thoracic aortopathy.Frontiers in cardiovascular medicine · 2022Article
- Comparative evaluation of coronary disease burden: bicuspid valve disease is not atheroprotective.Open heart · 2021Article
- Extent of Coronary Artery Disease in Patients With Stenotic Bicuspid Versus Tricuspid Aortic Valves.Journal of the American Heart Association · 2021Observational
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Bicuspid aortic valve (BAV) is the most common congenital cardiac malformation, which is often complicated by aortic valve stenosis (AoS). In tricuspid aortic valve (TAV), AoS strongly associates with coronary artery disease (CAD) with common pathophysiological factors. Yet, it remains unclear whether AoS in patients with BAV is also associated with CAD. This study investigated the association between the aortic valve morphological features and the extent of CAD. Methods and Results A single-center study was performed, including all patients who underwent an aortic valve replacement attributable to AoS between 2006 and 2019. Coronary sclerosis was graded on preoperative coronary angiographies using the coronary artery greater even than scoring method, which divides the coronaries in 28 segments and scores nonobstructive (20%-49% sclerosis) and obstructive coronary sclerosis (>49% sclerosis) in each segment. Multivariate analyses were performed, controlling for age, sex, and CAD risk factors. A total of 1296 patients (931 TAV and 365 BAV) were included, resulting in 548 matched patients. Patients with TAV exhibited more CAD risk factors (odds ratio [OR], 2.66; 95% CI, 1.79-3.96;
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