Heather Leduc-Pessah, Cynthia Xu, Churmy Y Fan, Rebecca Dalgarno, Yuta Kohro, Sydney Sparanese, Nikita N Burke, Kenneth A Jacobson, Christophe Altier, Daniela Salvemini and 1 more
Article in Journal of neuroscience research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
2 citing papers in PubMed, 7 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
11 authors at 3 institutions in 2 countries.
Heather Leduc-PessahDepartment of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, AB, Canada.
Cynthia XuDepartment of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, AB, Canada.
Churmy Y FanDepartment of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, AB, Canada.
Rebecca DalgarnoDepartment of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, AB, Canada.
Yuta KohroDepartment of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, AB, Canada.
Sydney SparaneseDepartment of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, AB, Canada.
Nikita N BurkeDepartment of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, AB, Canada.
Kenneth A JacobsonNational Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA.ORCID 0000-0001-8104-1493
Christophe AltierDepartment of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, AB, Canada.
Daniela SalveminiDepartment of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, MO, USA.
Tuan TrangDepartment of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, AB, Canada.ORCID 0000-0003-3309-9492
University of Calgary · CANational Institute of Diabetes and Digestive and Kidney Diseases · USSaint Louis University · US
Funding
Development Of Drugs Acting At Adenosine ReceptorsZIADK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$10.4M
Role of opioid-induced S1P/S1PR1 axis activation in neuroinflammatory reponsesR01DA043543 · NIDA · SAINT LOUIS UNIVERSITY · PI SALVEMINI, DANIELA, VANDERAH, TODD W · 2018 to 2020
$1.7M
Canadian Institutes for Health Research PJ8-169697Intramural NIH HHS ZIA DK031117NIDA NIH HHS R01 DA043543NIDDK NIH HHS ZIADK31117
6 · The paper itself
Abstract
Opioids are potent analgesics, but their pain-relieving effects diminish with repeated use. The reduction in analgesic potency is a hallmark of opioid analgesic tolerance, which hampers opioid pain therapy. In the central nervous system, opioid analgesia is critically modulated by adenosine, a purine nucleoside implicated in the beneficial and detrimental actions of opioid medications. Here, we focus on the A
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.