ArticleClinical cardiology2021
Gender differences in acute myocardial infarction-A nationwide German real-life analysis from 2014 to 2017.
Article in Clinical cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05619601 (Gender Differences in Prevention Strategies and Therapeutic Adherence After Acute Myocardial Infarction - GENAMI PREVENTION), which is not on this map. Cited by 37 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Gender Differences in Prevention Strategies and Therapeutic Adherence After Acute Myocardial Infarction - GENAMI PREVENTION
Who cites it
37 citing papers in PubMed, 64 citations in OpenAlex.
- Cost-effectiveness of early empagliflozin initiation after acute myocardial infarction: a German statutory health insurance perspective.Cost effectiveness and resource allocation : C/E · 2026Article
- Evolving trends and persistent challenges in chronic left ventricular heart failure management: insights from a 9-year analysis of in-hospital outcomes in Germany.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Sex-specific differences in disease severity and outcomes in left ventricular heart failure: a nationwide cohort study.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Multi-modal deep-learning troponin prediction from electrocardiograms and demographic data.European heart journal. Digital health · 2026Article
- Sex disparities in STEMI pathophysiology: Presentation, treatments, and outcomes.Global cardiology science & practice · 2026Review
- Coronary Artery Bypass Grafting Following ST Elevation Myocardial Infarction Outcomes Are Associated with Time to Surgery.Interdisciplinary cardiovascular and thoracic surgery · 2026Article
- Implementing gender-sensitive personalized nursing care into practice - a qualitative study with nurses from the cardiology units.BMC nursing · 2026Article
- Interplay of Atrial Arrhythmia and Chronic Heart Failure: A Population-Based Analysis of Hospital Outcomes in Germany.International journal of medical sciences · 2026Article
- Sex-specific outcomes in myocardial infarction: a dual-cohort analysis using clinical and real-world data.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Value of hs-cTnT, sST2, and Lp-PLA2 in the classification of acute coronary syndrome.Experimental and therapeutic medicine · 2025Article
- Article
- Enhanced prognosis and regional cooperative rescue systems for acute myocardial infarction: insights from chest pain centers in Ningxia, China.Internal and emergency medicine · 2025Article
- Sex-related differences in care and prognosis in acute coronary syndrome.Preventive medicine reports · 2025Article
- Sex-specific outcomes in acute myocardial infarction-associated cardiogenic shock treated with and without V-A ECMO: a retrospective German nationwide analysis from 2014 to 2018.Heart and vessels · 2025Article
- Sex Differences in the In-Hospital Mortality of Patients with Acute Myocardial Infarction: A Cross-Sectional Study in 36 Hospitals Across Germany.Medicina (Kaunas, Lithuania) · 2025Article
- Sex differences in in-hospital outcomes and readmission rates after percutaneous coronary intervention.Proceedings (Baylor University. Medical Center) · 2025Article
- Sex-based analysis of NSTEMI processes of care and outcomes by hospital: a nationwide cohort study.European heart journal. Quality of care & clinical outcomes · 2024Article
- Population and Co-Occurrence Characteristics of Diagnoses and Comorbidities in Coronary Artery Disease Patients: A Case Study from a Hospital in Guangxi, China.Bioengineering (Basel, Switzerland) · 2024Article
- OECD indicator 'AMI 30-day mortality' is neither comparable between countries nor suitable as indicator for quality of acute care.Clinical research in cardiology : official journal of the German Cardiac Society · 2024Article
- Healthy food diversity and the risk of major chronic diseases in the EPIC-Potsdam study.Scientific reports · 2024Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundFemale sex was reported to be associated with an unfavorable outcome in acute myocardial infarction (AMI). In this nationwide analysis we assessed sex differences in acute outcomes of AMI and recent trends in patient healthcare.
methodsWe analyzed 875 735 German cases hospitalized with a main diagnosis of ST- (STEMI) and non ST-elevation myocardial infarction (NSTEMI) between January 01 2014 and December 31 2017 regarding morbidity, in-hospital mortality and treatments. A multivariable logistic regression model was designed to evaluate the use of interventions and their impact on in-hospital mortality.
resultsSTEMI cases decreased from 72 894 in 2014 to 68 213 in 2017, with 70% assignable to men. Female sex was associated with older age (74 vs. 62 years), and higher prevalence of cardiovascular risk factors such as chronic kidney disease (19.2% vs. 12.5%), hypertension (69.0% vs. 65.0%) and left ventricular heart failure (36.0% vs. 32.1%). In NSTEMI, female sex was also associated with older age (78 vs. 71 years), and higher prevalence of cardiovascular risk factors such as chronic kidney disease (29.7% vs. 23.9%), hypertension (77.4% vs. 74.5%) and left ventricular heart failure (40.5% vs. 36.4%). Overall, 74.3% of female and 81.3% of male STEMI cases received percutaneous coronary intervention (PCI, p < 0.001). In NSTEMI, PCI was performed in 40.8% of female and 52.0% of male cases (p < 0.001). In-hospital mortality was notably increased in female patients with STEMI (15.0% vs. 9.6%; p < 0.001; OR 1.07; 95% CI 1.03-1.10) and NSTEMI (8.3% vs. 6.3%; p < 0.001; OR 0.91; 95% CI 0.89-0.93) compared to males.
conclusionsOur nationwide real-world data document that in-patient STEMI cases continue to decrease in women and men. The observed higher in-hospital mortality in women was largely attributed to a more unfavorable risk and age distribution rather than to female-intrinsic factors. Women with AMI continue to be less likely to receive revascularization therapies.
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