ArticleMedicine2021
[Role of the immune system in SARS-CoV-2 infection: immunopathology of COVID-19].
Article in Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- The Effects of Vitamin D Supplementation in COVID-19 Patients: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Programmed -1 ribosomal frameshifting in SARS-CoV-2: molecular mechanisms and implications for antiviral targeting.Virus genes · 2026Review
- Article
- Article
- Explanatory predictive model for COVID-19 severity risk employing machine learning, shapley addition, and LIME.Scientific reports · 2023Article
- Can Probiotics, ParticularlyBiology · 2023Review
- Clinical and pulmonary function analysis in long-COVID revealed that long-term pulmonary dysfunction is associated with vascular inflammation pathways and metabolic syndrome.Frontiers in medicine · 2023Article
- Alteration of the blood-brain barrier by COVID-19 and its implication in the permeation of drugs into the brain.Frontiers in cellular neuroscience · 2023Review
- Article
- Role of Innate and Adaptive Cytokines in the Survival of COVID-19 Patients.International journal of molecular sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The immune system is capable of adequately controlling SARS-CoV-2 infection in 81% of patients, whose disease is asymptomatic or who experience moderate symptoms. However, 19% of infected patients develop severe disease which can become critical or fatal. This review article intends to provide an overview of the epidemiological antecedents of β-coronaviruses, describe the mechanisms of SARS-CoV-2 infection, and summarize the rational immunological underpinnings known at present which allow for a better understanding of the immunopathology of COVID-19. The SARS-CoV-2 virus is capable of profoundly altering the behavior of molecular and cellular components of the immune system. The initial decisions of the innate immune system are responsible for a proper or improper response of the adaptive immune system and, along with comorbidities, are directly associated with disease progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.