Evidence map›Paper›PMID 34075227›Full record

ReviewNature reviews. Urology2021

Advances in sperm analysis: techniques, discoveries and applications.

Changsheng Dai, Zhuoran Zhang, Guanqiao Shan, Lap-Tak Chu, Zongjie Huang, Sergey Moskovtsev, Clifford Librach, Keith Jarvi, Yu Sun

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Methods for Investigating the Sperm Epigenome.Advances in experimental medicine and biology · 2026
    Review
  7. Article
  8. Antioxidant Activity ofVeterinary sciences · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Changsheng DaiDepartment of Mechanical and Industrial Engineering, University of Toronto, Toronto, Canada.ORCID http://orcid.org/0000-0002-8293-0097
Zhuoran ZhangDepartment of Mechanical and Industrial Engineering, University of Toronto, Toronto, Canada.ORCID http://orcid.org/0000-0002-8737-4210
Guanqiao ShanDepartment of Mechanical and Industrial Engineering, University of Toronto, Toronto, Canada.
Lap-Tak ChuDepartment of Mechanical and Industrial Engineering, University of Toronto, Toronto, Canada.
Zongjie HuangDepartment of Mechanical and Industrial Engineering, University of Toronto, Toronto, Canada.
Sergey MoskovtsevCReATe Fertility Centre, Toronto, Canada.
Clifford LibrachCReATe Fertility Centre, Toronto, Canada.
Keith JarviDivision of Urology, Mount Sinai Hospital, Toronto, Canada. Keith.Jarvi@sinaihealth.ca.ORCID http://orcid.org/0000-0001-6966-9114
Yu SunDepartment of Mechanical and Industrial Engineering, University of Toronto, Toronto, Canada. yu.sun@utoronto.ca.ORCID http://orcid.org/0000-0001-7895-0741

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infertility affects one in six couples worldwide, and fertility continues to deteriorate globally, partly owing to a decline in semen quality. Sperm analysis has a central role in diagnosing and treating male factor infertility. Many emerging techniques, such as digital holography, super-resolution microscopy and next-generation sequencing, have been developed that enable improved analysis of sperm motility, morphology and genetics to help overcome limitations in accuracy and consistency, and improve sperm selection for infertility treatment. These techniques have also improved our understanding of fundamental sperm physiology by enabling discoveries in sperm behaviour and molecular structures. Further progress in sperm analysis and integrating these techniques into laboratories and clinics requires multidisciplinary collaboration, which will increase discovery and improve clinical outcomes.

Indexed as

DNA FragmentationHumansInfertility, MaleMaleSemen AnalysisSpermatozoaSperm Injections, IntracytoplasmicSperm Motility

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.