Evidence map›Paper›PMID 34075133›Full record

ArticleScientific reports2021

Harnessing PET to track micro- and nanoplastics in vivo.

Outi Keinänen, Eric J Dayts, Cindy Rodriguez, Samantha M Sarrett, James M Brennan, Mirkka Sarparanta, Brian M Zeglis

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Microplastics, nanoplastics and liver disease: an emerging health concern?Nature reviews. Gastroenterology & hepatology · 2026
    Review
  3. In Vivo Microplastic Detection With Photoacoustic Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Tracking of [Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  5. Cell-nanoplastics association impacts cell proliferation and motility.bioRxiv : the preprint server for biology · 2026
    Article
  6. Review
  7. Article
  8. Article
  9. ComparativeDalton transactions (Cambridge, England : 2003) · 2025
    Article
  10. Article
  11. Article
  12. Rising Concern About the Carcinogenetic Role of Micro-Nanoplastics.International journal of molecular sciences · 2024
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Molecular Imaging, Radiochemistry, and Environmental Pollutants.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Outi KeinänenDepartment of Chemistry, Hunter College, City University of New York, 413 East 69th Street, New York, NY, 10021, USA. omk2009@med.cornell.edu.
Eric J DaytsDepartment of Chemistry, Hunter College, City University of New York, 413 East 69th Street, New York, NY, 10021, USA.
Cindy RodriguezDepartment of Chemistry, Hunter College, City University of New York, 413 East 69th Street, New York, NY, 10021, USA.
Samantha M SarrettDepartment of Chemistry, Hunter College, City University of New York, 413 East 69th Street, New York, NY, 10021, USA.
James M BrennanDepartment of Chemistry, Hunter College, City University of New York, 413 East 69th Street, New York, NY, 10021, USA.
Mirkka SarparantaDepartment of Chemistry, University of Helsinki, Helsinki, Finland.
Brian M ZeglisDepartment of Chemistry, Hunter College, City University of New York, 413 East 69th Street, New York, NY, 10021, USA. bz102@hunter.cuny.edu.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Elisa de Stanchina · 1985 to 2026
$347.4M
Pretargeted Clinical Imaging of CA19.9 in Pancreatic CancerU01CA221046 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S., ZEGLIS, BRIAN MATTHEW · 2018 to 2022
$3.5M
The Clinical PET Imaging of Metastatic Breast Cancer with Site-Specifically Labeled 89Zr-TrastuzumabR01CA204167 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S., ULANER, GARY ALLAN · 2016 to 2020
$3.4M
Novel Transgenic Mouse Models Addressing Outstanding Translational Barriers in Antibody-Based TherapeuticsR01CA244327 · NCI · ROCKEFELLER UNIVERSITY · PI BOURNAZOS, STYLIANOS · 2020 to 2024
$3.0M
Novel Reagents for Rapid and Stable Thiol-Based BioconjugationsR01CA240963 · NCI · HUNTER COLLEGE · PI ZEGLIS, BRIAN MATTHEW · 2019 to 2023
$1.6M
The Ivis Spectrum CT for Pre-Clinical Oncology ResearchS10OD016207 · OD · SLOAN-KETTERING INST CAN RESEARCH · PI ZANZONICO, PAT B · 2013 to 2013
$595k
SHARED INSTRUMENT: FOCUS MICROPET: CANCERS10RR020892 · NCRR · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI LARSON, STEVEN MARK · 2005 to 2005
$499k
A PET Radiotracer for Diagnostic and Theranostics Imaging in Lyme DiseaseR21EB030275 · NIBIB · HUNTER COLLEGE · PI QIU, WEIGANG, ZEGLIS, BRIAN MATTHEW · 2020 to 2021
$429k
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA204167NCI NIH HHS R01 CA240963NCI NIH HHS R01 CA244327NCI NIH HHS U01 CA221046NCRR NIH HHS S10 RR020892NIBIB NIH HHS R21 EB030275NIH HHS R01CA240963NIH HHS S10 OD016207
6 · The paper itself

Abstract

The proliferation of plastics in the environment continues at an alarming rate. Plastic particles have been found to be persistent and ubiquitous pollutants in a variety of environments, including sea water, fresh water, soil, and air. In light of this phenomenon, the scientific and medical communities have become increasingly wary of the dangers posed to human health by chronic exposure to microplastics (< 5 mm diameter) and nanoplastics (< 100 nm diameter). A critical component of the study of the health effects of these pollutants is the accurate determination of their pharmacokinetic behavior in vivo. Herein, we report the first use of molecular imaging to track polystyrene (PS) micro- and nanoplastic particles in mammals. To this end, we have modified PS particles of several sizes-diameters of 20 nm, 220 nm, 1 µm, and 6 µm-with the chelator desferrioxamine (DFO) and radiolabeled these DFO-bearing particles with the positron-emitting radiometal zirconium-89 (

Indexed as

MicroplasticsPolystyrenesPositron-Emission TomographyAnimalsFemaleHumansMiceNanoparticlesMicroplasticsPolystyrenes

Identifiers

PMID34075133
PMCPMC8169765

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.