Evidence map›Paper›PMID 34075120›Full record

ArticleScientific reports2021

Identification of Small Molecule Inhibitors of a Mir155 Transcriptional Reporter in Th17 Cells.

Anju Singh, Myagmarjav Dashynam, Bryan Chim, Thelma M Escobar, Xiuhuai Liu, Xin Hu, Samarjit Patnaik, Xin Xu, Noel Southall, Juan Marugan and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Anju SinghDivision of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), NIH, 9800 Medical Center Drive, Rockville, MD, 20850, USA. anju.singh@nih.gov.
Myagmarjav DashynamDivision of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), NIH, 9800 Medical Center Drive, Rockville, MD, 20850, USA.
Bryan ChimLaboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.
Thelma M EscobarLaboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.
Xiuhuai LiuLaboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.
Xin HuDivision of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), NIH, 9800 Medical Center Drive, Rockville, MD, 20850, USA.
Samarjit PatnaikDivision of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), NIH, 9800 Medical Center Drive, Rockville, MD, 20850, USA.
Xin XuDivision of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), NIH, 9800 Medical Center Drive, Rockville, MD, 20850, USA.
Noel SouthallDivision of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), NIH, 9800 Medical Center Drive, Rockville, MD, 20850, USA.
Juan MaruganDivision of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), NIH, 9800 Medical Center Drive, Rockville, MD, 20850, USA.
Ajit JadhavDivision of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), NIH, 9800 Medical Center Drive, Rockville, MD, 20850, USA.
Vanja LazarevicExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Stefan A MuljoLaboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA. stefan.muljo@nih.gov.
Marc FerrerDivision of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), NIH, 9800 Medical Center Drive, Rockville, MD, 20850, USA. marc.ferrer@nih.gov.
National Center for Advancing Translational Sciences · USNational Institute of Allergy and Infectious Diseases · USNational Institutes of Health · US

Funding

Roles of non-Coding RNAs in Programming Lymphocyte Differentiation and FunctionZIAAI001131 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MULJO, STEFAN · 2010 to 2025
$11.0M
Role of T-bet in the pathogenesis of experimental autoimmune encephalomyelitisZIABC011431 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LAZAREVIC, VANJA · 2012 to 2025
$9.7M
Transcriptional regulation of inflammatory and autoimmune responsesZIABC011765 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LAZAREVIC, VANJA · 2017 to 2025
$7.7M
6 · The paper itself

Abstract

MicroRNA miR-155 is an important regulatory molecule in the immune system and is highly expressed and functional in Th17 cells, a subset of CD4

Indexed as

Genes, ReporterAnimalsCytokinesDown-RegulationImidazolesMiceMice, TransgenicMicroRNAsTh17 CellsTranscription, GeneticCytokinesImidazolesMicroRNAsMirn155 microRNA, mouse

Identifiers

PMID34075120
PMCPMC8169650
OpenAlexW3165417120

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.