Evidence map›Paper›PMID 34075105›Full record

ArticleScientific reports2021

Functional and structural ophthalmic imaging using noncontact multimodal photoacoustic remote sensing microscopy and optical coherence tomography.

Zohreh Hosseinaee, Nima Abbasi, Nicholas Pellegrino, Layla Khalili, Lyazzat Mukhangaliyeva, Parsin Haji Reza

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Molecular and cellular imaging of the eye.Biomedical optics express · 2024
    Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Photoacoustic imaging for microcirculation.Microcirculation (New York, N.Y. : 1994) · 2022
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Zohreh HosseinaeePhotoMedicine Labs, Department of System Design Engineering, University of Waterloo, 200 University Ave W, Waterloo, ON, N2L 3G1, Canada.
Nima AbbasiPhotoMedicine Labs, Department of System Design Engineering, University of Waterloo, 200 University Ave W, Waterloo, ON, N2L 3G1, Canada.
Nicholas PellegrinoPhotoMedicine Labs, Department of System Design Engineering, University of Waterloo, 200 University Ave W, Waterloo, ON, N2L 3G1, Canada.
Layla KhaliliPhotoMedicine Labs, Department of System Design Engineering, University of Waterloo, 200 University Ave W, Waterloo, ON, N2L 3G1, Canada.
Lyazzat MukhangaliyevaPhotoMedicine Labs, Department of System Design Engineering, University of Waterloo, 200 University Ave W, Waterloo, ON, N2L 3G1, Canada.
Parsin Haji RezaPhotoMedicine Labs, Department of System Design Engineering, University of Waterloo, 200 University Ave W, Waterloo, ON, N2L 3G1, Canada. phajireza@uwaterloo.ca.
University of Waterloo · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early diagnosis of ocular diseases improves the understanding of pathophysiology and aids in accurate monitoring and effective treatment. Advanced, multimodal ocular imaging platforms play a crucial role in visualization of ocular components and provide clinicians with a valuable tool for evaluating various eye diseases. Here, for the first time we present a non-contact, multiwavelength photoacoustic remote sensing (PARS) microscopy and swept-source optical coherence tomography (SS-OCT) for in-vivo functional and structural imaging of the eye. The system provides complementary imaging contrasts of optical absorption and optical scattering, and is used for simultaneous, non-contact, in-vivo imaging of murine eye. Results of vasculature and structural imaging as well as melanin content in the retinal pigment epithelium layer are presented. Multiwavelength PARS microscopy using Stimulated Raman scattering is applied to enable in-vivo, non-contact oxygen saturation estimation in the ocular tissue. The reported work may be a major step towards clinical translation of ophthalmic technologies and has the potential to advance the diagnosis and treatment of ocular diseases.

Indexed as

MicroscopyMultimodal ImagingPhotoacoustic TechniquesRemote Sensing TechnologyTomography, Optical CoherenceAnimalsMiceMice, NudeRetinal Pigment Epithelium

Identifiers

PMID34075105
PMCPMC8169886
OpenAlexW3165552662

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.