Evidence map›Paper›PMID 34075045›Full record

ArticleNPJ breast cancer2021

The impact of lymphedema on health-related quality of life up to 10 years after breast cancer treatment.

Mads G Jørgensen, Navid M Toyserkani, Frederik G Hansen, Anette Bygum, Jens A Sørensen

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ breast cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05441943 (Lymphaticovenous Anastomosis as a Surgical Treatment for Breast Cancer-Related Lymphedema), which is not on this map. Cited by 74 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 6 pooled it
5.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05441943 naactive not recruitingnot on this mapstarted 2022, after this paper: background citation

Lymphaticovenous Anastomosis as a Surgical Treatment for Breast Cancer-Related Lymphedema

TypeinterventionalSponsorOdense University HospitalRan2022 to 2026Enrolled10ConditionsBreast Cancer Lymphedema, Secondary Lymphedema, Iatrogenic Lymphedema, LymphedemaArmsLymphovenous anastomosis
3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 6 syntheses or guidelines pooled it, 114 citations in OpenAlex.

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  11. Preventive effects of progressive resistance training of different intensities on breast cancer-related lymphedema.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  13. Impact of text reminders on pneumatic compression device (PCD) compliance in patients with breast cancer-related lymphedema.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mads G JørgensenDepartment of Plastic Surgery, Research Unit for Plastic Surgery, Odense University Hospital, Odense, Denmark. Mads.Gustaf.Jorgensen@rsyd.dk.ORCID http://orcid.org/0000-0002-8755-3446
Navid M ToyserkaniDepartment of Plastic Surgery and Burns Treatment, Rigshospitalet, Copenhagen, Denmark.
Frederik G HansenDepartment of Plastic Surgery, Research Unit for Plastic Surgery, Odense University Hospital, Odense, Denmark.
Anette BygumClinical Institute, University of Southern Denmark, Odense, Denmark.
Jens A SørensenDepartment of Plastic Surgery, Research Unit for Plastic Surgery, Odense University Hospital, Odense, Denmark.
University of Southern Denmark · DKRigshospitalet · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The impact of breast cancer-related lymphedema (BCRL) on long-term quality of life is unknown. The aim of this study was to investigate the impact of BCRL on health-related quality of life (HRQoL) up to 10 years after breast cancer treatment. This regional population-based study enrolled patients treated for breast cancer with axillary lymph node dissection between January 1st 2007 and December 31th 2017. Follow up and assessments of the included patients were conducted between January 2019 and May 2020. The study outcome was HRQoL, evaluated with the Lymphedema Functioning, Disability and Health Questionnaire, the Disabilities of the Arm, Shoulder and Hand Questionnaire and the Short Form (36) Health Survey Questionnaire. Multivariate linear logistic regression models adjusted for confounders provided mean score differences (MDs) with 95% confidence intervals in each HRQoL scale and item. This study enrolled 244 patients with BCRL and 823 patients without BCRL. Patients with BCRL had significantly poorer HRQoL than patients without BCRL in 16 out of 18 HRQoL subscales, for example, in physical function (MDs 27, 95%CI: 24; 30), mental health (MDs 24, 95%CI: 21; 27) and social role functioning (MDs 20, 95%CI: 17; 23). Age, BMI, BCRL severity, hand and dominant arm affection had only minor impact on HRQoL (MDs < 5), suggesting a high degree of inter-individual variation in coping with lymphedema. This study showed that BCRL is associated with long-term impairments in HRQoL, especially affecting the physical and psychosocial domains. Surprisingly, BCRL diagnosis rather than clinical severity drove the largest impairments in HRQoL.

Identifiers

PMID34075045
PMCPMC8169644
OpenAlexW3164466088

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.