Evidence map›Paper›PMID 34074933›Full record

ReviewJournal of the Chinese Medical Association : JCMA2021

Clinical significance of olfactory dysfunction in patients of COVID-19.

Chin-Chuan Chang, Ming-Hui Yang, Shu-Min Chang, Ya-Ju Hsieh, Che-Hsin Lee, Yi-Ming Arthur Chen, Cheng-Hui Yuan, Yi-Ling Chen, Sheng-Yow Ho, Yu-Chang Tyan

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of the Chinese Medical Association : JCMA, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 2 countries.

Chin-Chuan ChangDepartment of Nuclear Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC.
Ming-Hui YangDepartment of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROC.
Shu-Min ChangDepartment of Nuclear Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC.
Ya-Ju HsiehDepartment of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.
Che-Hsin LeeDepartment of Biological Science, National Sun Yat-sen University, Kaohsiung, Taiwan, ROC.
Yi-Ming Arthur ChenGraduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City, Taiwan, ROC.
Cheng-Hui YuanMass Spectrometry Laboratory, Department of Chemistry, National University of Singapore, Singapore.
Yi-Ling ChenDepartment of Nuclear Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC.
Sheng-Yow HoDepartment of Radiation Oncology, Chi Mei Medical Center, Tainan, Taiwan, ROC.
Yu-Chang TyanSchool of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.
Kaohsiung Medical University · TWNational Sun Yat-sen University · TWChang Jung Christian University · TWFu Jen Catholic University · TWI-Shou University · TWMin-Hwei College of Health Care Management · TWNational Health Research Institutes · TWNational University of Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCurrently, as the coronavirus disease (COVID-19) has become a pandemic, rapidly obtaining accurate information of patient symptoms and their progression is crucial and vital. Although the early studies in China have illustrated that the representative symptoms of COVID-19 include (dry) cough, fever, headache, fatigue, gastrointestinal discomfort, dyspnea, and muscle pain, there is increasing evidence to suggest that olfactory and taste disorder are related to the COVID-19 pandemic. Therefore, we conduct this study to review the present literature about the correlation between anosmia or dysgeusia and COVID-19.

methodsA comprehensive literature search in 2020 of the electronic journal databases, mainly PubMed or Web of Science, was performed using the keywords COVID-19 or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with hyposmia, anosmia, dysgeusia, olfactory disorder, or olfactory dysfunction. The country, study period, case number, inpatient or outpatient medical visit, evaluation method (subjective complaints of dysfunction or objective evaluation), and occurrence rate of olfactory or gustatory function were reviewed.

resultsMany studies reported that the recoverable olfactory or gustatory dysfunction may play an important role as the early clinical symptom of COVID-19. It is associated with better prognosis, although further investigation and validation should be carried out.

conclusionStudies have shown that smell and taste disturbances may represent an early symptom of COVID-19 and healthcare professionals must be very vigilant when managing patients with these symptoms. In the pandemic era, this implies testing for COVID-19 by healthcare workers with full personal protective equipment.

Indexed as

SARS-CoV-2Angiotensin-Converting Enzyme 2COVID-19COVID-19 TestingHumansOlfaction DisordersTaste DisordersACE2 protein, humanAngiotensin-Converting Enzyme 2

Identifiers

PMID34074933
PMCPMC12966048
OpenAlexW3164836326

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.