Evidence map›Paper›PMID 34074802›Full record

ArticleAging2021

Association of growth hormone receptor gene variant with longevity in men is due to amelioration of increased mortality risk from hypertension.

Timothy A Donlon, Randi Chen, Kamal H Masaki, D Craig Willcox, Richard C Allsopp, Bradley J Willcox, Brian J Morris

Open access · hybridAbstract read
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Timothy A DonlonDepartment of Research, Kuakini Medical Center, Honolulu, HI 96817, USA.
Randi ChenDepartment of Research, Kuakini Medical Center, Honolulu, HI 96817, USA.
Kamal H MasakiDepartment of Research, Kuakini Medical Center, Honolulu, HI 96817, USA.
D Craig WillcoxDepartment of Research, Kuakini Medical Center, Honolulu, HI 96817, USA.
Richard C AllsoppInstitute for Biogenesis Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96822, USA.
Bradley J WillcoxDepartment of Research, Kuakini Medical Center, Honolulu, HI 96817, USA.
Brian J MorrisDepartment of Research, Kuakini Medical Center, Honolulu, HI 96817, USA.
Kuakini Medical Center · USUniversity of Hawaiʻi at Mānoa · USOkinawa International University · JP

Funding

University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI GERTRAUD MASKARINEC · 1996 to 2026
$56.2M
Epidemiology of Brain Aging in the Very OldU01AG019349 · NIA · KUAKINI MEDICAL CENTER · PI WHITE, LON RAY · 2001 to 2011
$14.0M
Productive and Leisure Activities and Cognition in Later LifeP20GM125526 · NIGMS · KUAKINI MEDICAL CENTER · PI WILLCOX, BRADLEY JOHN · 2019 to 2023
$12.0M
FOXO3 Genotype, InflammAging, Cardiovascular Disease, and Dementia. Kuakini Hawaii Lifespan Study III. Administrative Supplement.R01AG027060 · NIA · KUAKINI MEDICAL CENTER · PI Gregory J. Tranah, BRADLEY JOHN WILLCOX · 2005 to 2026
$8.1M
Energy-sensing Pathways, Healthy Aging and LongevityR01AG038707 · NIA · KUAKINI MEDICAL CENTER · PI WILLCOX, BRADLEY JOHN · 2011 to 2014
$1.4M
HONOLULU HEART PROGRAMN01HC005102 · HC · KUAKINI MEDICAL CENTER · PI CURB, JESS DAVID · 1990 to 1997
–
NCI NIH HHS P30 CA071789NHLBI NIH HHS N01 HC005102NIA NIH HHS R01 AG027060NIA NIH HHS R01 AG038707NIA NIH HHS U01 AG019349NIGMS NIH HHS P20 GM125526
6 · The paper itself

Abstract

The single nucleotide polymorphism (SNP)

Indexed as

Genetic VariationAgedBlood GlucoseBody Mass IndexGenotypeHumansHypertensionLongevityMaleMolecular Sequence AnnotationPolymorphism, Single NucleotideReceptors, SomatotropinRisk FactorsSurvival AnalysisBlood GlucoseReceptors, Somatotropingrowth hormone receptorhypertensionlongevitymortality

Identifiers

PMID34074802
PMCPMC8221335
OpenAlexW3164057765

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.