ArticleProceedings of the National Academy of Sciences of the United States of America2021
Identifying the origin of local flexibility in a carbohydrate polymer.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Landing-Energy-Controlled Surface Conformation of Electrosprayed Foldamer Molecules on Au(111).ACS nano · 2026Article
- Self-Assembly, Rearrangement, and Disassembly of {CrAngewandte Chemie (International ed. in English) · 2025Article
- Glycoproteins in Viruses.Methods in molecular biology (Clifton, N.J.) · 2025Review
- Scanning Probe Microscopy Characterization of Biomolecules enabled by Mass-Selective, Soft-landing Electrospray Ion Beam Deposition.Chemphyschem : a European journal of chemical physics and physical chemistry · 2024Article
- Atomically resolved imaging of the conformations and adsorption geometries of individual β-cyclodextrins with non-contact AFM.Nature communications · 2024Article
- Synthesis and screening of a library of LewisNature communications · 2024Article
- Molecular sensitised probe for amino acid recognition within peptide sequences.Nature communications · 2023Article
- Direct observation of glycans bonded to proteins and lipids at the single-molecule level.Science (New York, N.Y.) · 2023Article
- Navigate Flying Molecular Elephants Safely to the Ground: Mass-Selective Soft Landing up to the Mega-Dalton Range by Electrospray Controlled Ion-Beam Deposition.Analytical chemistry · 2022Article
- Assessing the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans by Structural and Computational Methods.Frontiers in microbiology · 2022Article
- O-Methylation in Carbohydrates: An NMR and MD Simulation Study with Application to Methylcellulose.The journal of physical chemistry. B · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Correlating the structures and properties of a polymer to its monomer sequence is key to understanding how its higher hierarchy structures are formed and how its macroscopic material properties emerge. Carbohydrate polymers, such as cellulose and chitin, are the most abundant materials found in nature whose structures and properties have been characterized only at the submicrometer level. Here, by imaging single-cellulose chains at the nanoscale, we determine the structure and local flexibility of cellulose as a function of its sequence (primary structure) and conformation (secondary structure). Changing the primary structure by chemical substitutions and geometrical variations in the secondary structure allow the chain flexibility to be engineered at the single-linkage level. Tuning local flexibility opens opportunities for the bottom-up design of carbohydrate materials.
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