ArticleProceedings of the National Academy of Sciences of the United States of America2021
Transposon-mediated insertional mutagenesis unmasks recessive insecticide resistance in the aphid
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Target-site mutations and phenotypic failure in Myzus persicae against pyrethroids and carbamates in central Europe.Pest management science · 2026Article
- Evolutionary genomics and divergence of Cacopsylla species with a special focus on the apple proliferation vectors Cacopsylla melanoneura and Cacopsylla picta.BMC genomics · 2026Article
- Historic transposon mobilisation waves create distinct pools of adaptive variants in a major crop pathogen.Nature communications · 2025Article
- Chromosome-level genome assembly of soybean aphid.Scientific data · 2025Article
- Host plant flooding stress in soybeans differentially impacts avirulent and virulent soybean aphid (Aphis glycines) biotypes.Scientific reports · 2025Article
- Geographical distribution of pyrethroid resistance mutations in Varroa destructor across Türkiye and a European overview.Experimental & applied acarology · 2024Article
- Transposon accumulation at xenobiotic gene family loci in aphids.Genome research · 2023Article
- Hybridisation has shaped a recent radiation of grass-feeding aphids.BMC biology · 2023Article
- Variation of insulin-related peptides accompanying the differentiation ofEcology and evolution · 2023Article
- Retrotransposon-mediated evolutionary rewiring of a pathogen response orchestrates a resistance phenotype in an insect host.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Transposable elements and xenobiotic resistance.Frontiers in insect science · 2023Review
- Host plants and insecticides shape the evolution of genetic and clonal diversity in a major aphid crop pest.Evolutionary applications · 2022Article
- New Delhi Metallo-Beta-Lactamase Facilitates the Emergence of Cefiderocol Resistance in Enterobacter cloacae.Antimicrobial agents and chemotherapy · 2022Article
- The Dynamism of Transposon Methylation for Plant Development and Stress Adaptation.International journal of molecular sciences · 2021Review
- Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aphid crop pest Myzus persicae.Communications biology · 2021Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
The evolution of resistance to insecticides threatens the sustainable control of many of the world's most damaging insect crop pests and disease vectors. To effectively combat resistance, it is important to understand its underlying genetic architecture, including the type and number of genetic variants affecting resistance and their interactions with each other and the environment. While significant progress has been made in characterizing the individual genes or mutations leading to resistance, our understanding of how genetic variants interact to influence its phenotypic expression remains poor. Here, we uncover a mechanism of insecticide resistance resulting from transposon-mediated insertional mutagenesis of a genetically dominant but insecticide-susceptible allele that enables the adaptive potential of a previously unavailable recessive resistance allele to be unlocked. Specifically, we identify clones of the aphid pest
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