ArticleProceedings of the National Academy of Sciences of the United States of America2021
Krüppel-like factor 6-mediated loss of BCAA catabolism contributes to kidney injury in mice and humans.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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51citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Blood metabolome of cardiovascular disease, diabetic kidney disease, and diabetic retinopathy in type 2 diabetes patients: A systematic review and meta-analysis.Endocrine research · 2025Pooled it
- Article
- Methylcrotonyl-CoA carboxylase 2 supports leucine catabolism to promote mitochondrial biogenesis and alleviate cisplatin-induced acute kidney injury.Kidney research and clinical practice · 2026Article
- Article
- Dietary intake and BCAA metabolism regulate pulmonary fibrosis through KDM4A-mediated epigenetic remodeling in male mice.Nature communications · 2026Article
- Targeting amino acid metabolic pathways: a novel therapeutic strategy for hyperuricemia-associated complications.Amino acids · 2026Review
- Podocyte-Specific Deletion of STAT3 in Krüppel-Like Factor 4-Related Experimental Podocytopathy.Journal of the American Society of Nephrology : JASN · 2026Article
- Review
- Impact of gut microbiota in chronic kidney disease: natural polyphenols as beneficial regulators.Renal failure · 2025Review
- Effect of chronic kidney disease and type 2 diabetes on plasma branched-chain amino acid cross-correlation: a novel metric for evaluating homeostasis.Journal of clinical biochemistry and nutrition · 2025Article
- Krüppel-Like Factor 6 Induces RNA Polymerase II Subunit RPB1 to Promote Kidney Injury.Journal of the American Society of Nephrology : JASN · 2025Article
- Branched-chain amino acids contribute to diabetic kidney disease progression via PKM2-mediated podocyte metabolic reprogramming and apoptosis.Nature communications · 2025Article
- Emerging Insights into the Relationship Between Amino Acid Metabolism and Diabetic Cardiomyopathy.Biomolecules · 2025Review
- Transcriptional Regulators in the Cerebellum in Chronic Schizophrenia: Novel Possible Targets for Pharmacological Interventions.International journal of molecular sciences · 2025Article
- Fueling kidney recovery: boosting BCAA metabolism to overcome nephrotoxic AKI.American journal of physiology. Renal physiology · 2025Article
- Acute kidney injury through a metabolic lens: pathological reprogramming mechanisms and clinical translation potential.Frontiers in physiology · 2025Review
- Activation of branched chain amino acid catabolism protects against nephrotoxic acute kidney injury.American journal of physiology. Renal physiology · 2025Article
- Influence of gut flora on diabetes management after kidney transplantation.BMC nephrology · 2024Review
- Exploring the Functionality of the Krüppel-like Factors in Kidney Development, Metabolism, and Diseases.Life (Basel, Switzerland) · 2024Review
- Amino acid metabolism in kidney health and disease.Nature reviews. Nephrology · 2024Review
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 1 country.
Sian E PiretDivision of Nephrology, Department of Medicine, Stony Brook University, Stony Brook, NY 11794.ORCID 0000-0002-3586-7654
Yiqing GuoDivision of Nephrology, Department of Medicine, Stony Brook University, Stony Brook, NY 11794.
Ahmed A AttallahDivision of Nephrology, Department of Medicine, Stony Brook University, Stony Brook, NY 11794.ORCID 0000-0001-5511-0168
Sylvia J HorneDivision of Nephrology, Department of Medicine, Stony Brook University, Stony Brook, NY 11794.ORCID 0000-0002-5917-4721
Amy ZollmanDepartment of Medicine, Indiana University, Indianapolis, IN 46202.
Daniel OwusuDivision of Nephrology, Department of Medicine, Stony Brook University, Stony Brook, NY 11794.
Justina HeneinDivision of Nephrology, Department of Medicine, Stony Brook University, Stony Brook, NY 11794.ORCID 0000-0002-1796-1428
Viktoriya S SidorenkoDepartment of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794.ORCID 0000-0002-3881-5702
Monica P ReveloDepartment of Pathology, University of Utah, Salt Lake City, UT 84112.ORCID 0000-0002-5746-408X
Takashi HatoDepartment of Medicine, Indiana University, Indianapolis, IN 46202.ORCID 0000-0002-0446-6575
Avi Ma'ayanDepartment of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, New York, NY 10029.ORCID 0000-0002-6904-1017
John Cijiang HeDepartment of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Sandeep K MallipattuDivision of Nephrology, Department of Medicine, Stony Brook University, Stony Brook, NY 11794; sandeep.mallipattu@stonybrookmedicine.edu.ORCID 0000-0002-6324-7807
Stony Brook University · USIndiana University – Purdue University Indianapolis · USIcahn School of Medicine at Mount Sinai · USJames J. Peters VA Medical Center · USNorthport VA Medical Center · USUniversity of Utah · US
Funding
Data Coordination and Integration Center for LINCS-BD2KU54HL127624 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MA'AYAN, AVI, SCHURER, STEPHAN C · 2014 to 2019
$23.5MUAB-UCSD O'Brien Core Center for Acute Kidney Injury ResearchP30DK079337 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SANDERS, PAUL W. · 2008 to 2022
$18.3MTranscriptional control of mitochondrial function by KLF6 in diabetic kidney diseaseR01DK112984 · NIDDK · STATE UNIVERSITY NEW YORK STONY BROOK · PI Sandeep K Mallipattu · 2017 to 2026
$3.5MMechanisms mediating podocyte-parietal epithelial cell crosstalk in proliferative glomerulopathiesR01DK121846 · NIDDK · STATE UNIVERSITY NEW YORK STONY BROOK · PI HE, JOHN CIJIANG, MALLIPATTU, SANDEEP K · 2020 to 2024
$2.7MKnowledge Management Center for Illuminating the Druggable GenomeU24CA224260 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MA'AYAN, AVI · 2018 to 2023
$1.5MModulating purine metabolism to treat kidney injury in sepsis.K08DK113223 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI HATO, TAKASHI · 2017 to 2021
$757kMolecular and cellular mechanisms underlying the carcinogenicity and nephrotoxicity of aristolochic acid: hallmarks of a global environmental diseaseR56ES029514 · NIEHS · STATE UNIVERSITY NEW YORK STONY BROOK · PI SIDORENKO, VIKTORIYA S · 2019 to 2019
$279kRole of KLF15 in proximal tubule metabolismI01BX003698 · VA · NORTHPORT VA MEDICAL CENTER · PI Sandeep K Mallipattu · 2018 to 2026
–BLRD VA I01 BX003698BLRD VA I01 BX005300NCI NIH HHS U24 CA224260NHLBI NIH HHS U54 HL127624NIDDK NIH HHS K08 DK113223NIDDK NIH HHS P30 DK079337NIDDK NIH HHS R01 DK112984NIDDK NIH HHS R01 DK121846NIEHS NIH HHS R56 ES029514
Abstract
Altered cellular metabolism in kidney proximal tubule (PT) cells plays a critical role in acute kidney injury (AKI). The transcription factor Krüppel-like factor 6 (KLF6) is rapidly and robustly induced early in the PT after AKI. We found that PT-specific
Indexed as
Acute Kidney InjuryAmino Acids, Branched-ChainAnimalsDisease Models, AnimalGene Expression RegulationGene Knockdown TechniquesHumansInflammationKidneyKidney Tubules, ProximalKruppel-Like Factor 6Kruppel-Like Transcription FactorsMiceTranscription FactorsAmino Acids, Branched-ChainKLF6 protein, humanKlf6 protein, mouseKruppel-Like Factor 6Kruppel-Like Transcription FactorsTranscription Factorsacute kidney injurybranched-chain amino acidskidneyproximal tubuletranscription factor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.