Evidence map›Paper›PMID 34074759›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Biosynthesis of fosfomycin in pseudomonads reveals an unexpected enzymatic activity in the metallohydrolase superfamily.

Max A Simon, Chayanid Ongpipattanakul, Satish K Nair, Wilfred A van der Donk

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Discovery of the Phosphonate Flavophos Produced byJournal of the American Chemical Society · 2026
    Article
  2. Discovery of the Phosphonate Flavophos Produced bybioRxiv : the preprint server for biology · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Max A SimonDepartment of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801.ORCID 0000-0002-4183-8040
Chayanid OngpipattanakulCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801.ORCID 0000-0003-1421-2410
Satish K NairCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801; snair@illinois.edu vddonk@illinois.edu.ORCID 0000-0003-1790-1334
Wilfred A van der DonkDepartment of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801; snair@illinois.edu vddonk@illinois.edu.ORCID 0000-0002-5467-7071
University of Illinois Urbana-Champaign · US

Funding

Structural Elucidation and Biosynthesis P01GM077596 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI METCALF, WILLIAM W · 2007 to 2016
$15.3M
Request for a Varian 600 MHz NMR InstrumentS10RR028833 · NCRR · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI VAN DER DONK, WILFRED A. · 2011 to 2011
$600k
Howard Hughes Medical InstituteNCRR NIH HHS S10 RR028833NIGMS NIH HHS P01 GM077596
6 · The paper itself

Abstract

The epoxide-containing phosphonate natural product fosfomycin is a broad-spectrum antibiotic used in the treatment of cystitis. Fosfomycin is produced by both the plant pathogen

Indexed as

FosfomycinBacterial ProteinsHydrolasesMetalloproteinsPseudomonas syringaeBacterial ProteinsFosfomycinHydrolasesMetalloproteinsdecarboxylasefosfomycinmetallohydrolasenonheme ironphosphonate

Identifiers

PMID34074759
PMCPMC8201877
OpenAlexW3164851678

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.