Trial reportProceedings of the National Academy of Sciences of the United States of America2021
Attention bias modification in drug addiction: Enhancing control of subsequent habits.
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Effects of behavioral interventions on stress reactivity in adults with substance use disorders.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2024Trial
- Peer-guided movie neurofeedback to facilitate recovery in opioid use disorder.medRxiv : the preprint server for health sciences · 2026Article
- Attentional bias toward emotional and cigarette cues: Insights from a computer mouse-tracking task in adults who smoke and adults who do not smoke.Drug and alcohol dependence · 2026Article
- Effect of attentional bias modification on social media addiction: a visual dot-probe task.Frontiers in psychology · 2026Article
- Drug-Specific Global Attentional Bias in Females with Drug Use Disorder: Response Slowing Under Short but Not Long Cue Exposure.Brain sciences · 2025Article
- Speak and You Shall Predict: Evidence That Speech at Initial Cocaine Abstinence Is a Biomarker of Long-Term Drug Use Behavior.Biological psychiatry · 2025Article
- Cocaine Cues Used in Experimental Research: A Systematic Review.Brain sciences · 2025Review
- Attentional bias towards smartphone stimuli is associated with decreased interoceptive awareness and increased physiological reactivity.Communications psychology · 2025Article
- Context-dependent Impulsivity in Substance Use Disorder: A Neuroscience-informed Framework.Current addiction reports · 2025Article
- Decoding and modifying dynamic attentional bias in gaming disorder.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- The Neurocircuitry of Substance Use Disorder, Treatment, and Change: A Resource for Clinical Psychiatrists.The American journal of psychiatry · 2024Review
- Stress and substance use disorders: risk, relapse, and treatment outcomes.The Journal of clinical investigation · 2024Review
- Behavioral therapies targeting reward mechanisms in substance use disorders.Pharmacology, biochemistry, and behavior · 2024Review
- Intrinsic Functional Connectivity between the Anterior Insular and Retrosplenial Cortex as a Moderator and Consequence of Cocaine Self-Administration in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Association of Cortico-Striatal Engagement During Cue Reactivity, Reappraisal, and Savoring of Drug and Non-Drug Stimuli With Craving in Heroin Addiction.The American journal of psychiatry · 2024Article
- Attentional biases in abstinent patients with cocaine use disorder: rapid orienting or delayed disengagement?Frontiers in psychology · 2024Article
- Comparison of Maslow's hierarchy of needs, decision-making, and attention control in individuals with sex addiction and normal people.Journal of education and health promotion · 2024Article
- Assessing cocaine motivational value: Comparison of brain reactivity bias toward cocaine cues and cocaine demand.Experimental and clinical psychopharmacology · 2023Article
- Increased attention allocation to stimuli reflecting end-states of compulsive behaviors among obsessive compulsive individuals.Scientific reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
A relapse in addiction is often precipitated by heightened attention bias to drug-related cues, underpinned by a subcortically mediated transition to habitual/automatized responding and reduced prefrontal control. Modification of such automatized attention bias is a fundamental, albeit elusive, target for relapse reduction. Here, on a trial-by-trial basis, we used electroencephalography and eye tracking with a task that assessed, in this order, drug cue reactivity, its instructed self-regulation via reappraisal, and the immediate aftereffects on spontaneous (i.e., not instructed and automatized) attention bias. The results show that cognitive reappraisal, a facet of prefrontal control, decreased spontaneous attention bias to drug-related cues in cocaine-addicted individuals, more so in those with less frequent recent use. The results point to the mechanisms underlying the disruption of automatized maladaptive drug-related attention bias in cocaine addiction. These results pave the way for future studies to examine the role of such habit disruption in reducing compulsive drug seeking outside the controlled laboratory environment, with the ultimate goal of developing a readily deployable cognitive-behavioral and personalized intervention for drug addiction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.